Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination
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DOI: 10.1038/s41541-020-0179-4
Abstract: The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56 + NK cell numbers, NKG2D or NKp30 surface receptor expression,… read more here.
Keywords: rvsv zebov; zebov ebolavirus; cell; rvsv ... See more keywords
Mucosal Delivery of Recombinant Vesicular Stomatitis Virus Vectors Expressing Envelope Proteins of Respiratory Syncytial Virus Induces Protective Immunity in Cotton Rats
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DOI: 10.1128/jvi.02345-20
Abstract: Even after decades of intensive research efforts, a safe and efficacious RSV vaccine remains elusive. Expression of heterologous antigens from rVSV vectors has demonstrated several practical and safety advantages over other virus vector systems and… read more here.
Keywords: cotton; rsv; rvsv; virus ... See more keywords
Development of an Integrated Continuous Manufacturing Process for the rVSV-Vectored SARS-CoV-2 Candidate Vaccine
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DOI: 10.3390/vaccines11040841
Abstract: The administration of viral vectored vaccines remains one of the most effective ways to respond to the ongoing novel coronavirus disease 2019 (COVID-19) pandemic. However, pre-existing immunity to the viral vector hinders its potency, resulting… read more here.
Keywords: manufacturing process; rvsv; sars cov; candidate vaccine ... See more keywords