Production of rVSV-ZEBOV in serum-free suspension culture of HEK 293SF cells.
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DOI: 10.1016/j.vaccine.2019.09.044
Abstract: Ebola virus disease is an urgent international priority. Promising results for several vaccine candidates have been reported in non-human primate studies and clinical trials with the most promising being the rVSV-ZEBOV vaccine. In this study,… read more here.
Keywords: production; hek 293sf; rvsv zebov; 293sf cells ... See more keywords
Humoral and cellular immune response induced by rVSVΔG-ZEBOV-GP vaccine among frontline workers during the 2013–2016 West Africa Ebola outbreak in Guinea
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DOI: 10.1016/j.vaccine.2020.04.066
Abstract: Highlights • We found rVSVΔG-ZEBOV-GP to be immunogenic at 28- and 180-days post vaccination.• At 28 days post-vaccination, seroresponse rate was higher in the high-risk group.• There is a significant pairwise correlation at 28 days… read more here.
Keywords: response; rvsv zebov; days post; post vaccination ... See more keywords
Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination
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DOI: 10.1038/s41541-020-0179-4
Abstract: The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56 + NK cell numbers, NKG2D or NKp30 surface receptor expression,… read more here.
Keywords: rvsv zebov; zebov ebolavirus; cell; rvsv ... See more keywords
Immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccination in exposed and potentially exposed persons in the Democratic Republic of the Congo
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DOI: 10.1073/pnas.2118895119
Abstract: Significance This paper describes findings from a seroepidemiologic study involving a cohort of Ebola-vaccinated individuals from North Kivu, Democratic Republic of the Congo (DRC), who were studied as part of a collaborative effort between American… read more here.
Keywords: vaccination; rvsv zebov; antibody; antibody response ... See more keywords
SAFETY OF RVSV EBOLA VACCINE, AFTER 6 MONTHS FOLLOW-UP, IN ADULTS: A PHASE 1 TRIAL CONDUCTED IN LAMBARÉNÉ, GABON
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DOI: 10.1136/bmjgh-2016-000260.179
Abstract: Introduction The Centre de Recherches Médicales de Lambaréné (CERMEL) in Gabon, member of the ‘VSV-EBola CONsortium’ (VEBCON), evaluated safety and immunogenicity of the rVSV∆G-ZEBOV-GP vaccine in African volunteers from an area with previous Ebola outbreaks… read more here.
Keywords: rvsv zebov; lambar gabon; safety; phase trial ... See more keywords
PO 8559 ASSESSMENT OF THE EFFECT OF RVSV REPLICATION ON NON-EBOLA CIRCULATING ANTIBODIES IN RVSV-ZEBOV-GP-VACCINATED INDIVIDUALS IN LAMBARÉNÉ, GABON
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DOI: 10.1136/bmjgh-2019-edc.138
Abstract: Background The West Africa Ebola virus disease (EVD) outbreak between 2015 and 2016 accelerated the need for safe and effective vaccines. Among candidate vaccines in clinical development, the recombinant Vesicular stomatitis virus (VSV) vectored with… read more here.
Keywords: circulating antibodies; replication non; virus; zebov ... See more keywords
Ervebo (Ebola Zaire Vaccine, Live/rVSVΔG-ZEBOV-GP): The First Licensed Vaccine for the Prevention of Ebola Virus Disease
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DOI: 10.1177/8755122520950692
Abstract: Objective: To review the clinical data regarding the safety and efficacy of the Ervebo (Ebola Zaire vaccine, live/rVSVΔG-ZEBOV-GP) vaccine for the prevention of the Ebola virus disease. Data Sources: A literature search through PubMed, MEDLINE,… read more here.
Keywords: rvsv zebov; ebola zaire; ebola; vaccine ... See more keywords
Lessons Learned from the Development and Roll-Out of the rVSVΔG-ZEBOV-GP Zaire ebolavirus Vaccine to Inform Marburg Virus and Sudan ebolavirus Vaccines
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DOI: 10.3390/vaccines10091446
Abstract: This review describes key aspects of the development of the rVSVΔG-ZEBOV-GP Ebola vaccine and key activities which are continuing to further expand our knowledge of the product. Extensive partnerships and innovative approaches were used to… read more here.
Keywords: rvsv zebov; ebolavirus; development; vaccine ... See more keywords