Different effects of running wheel exercise and skilled reaching training on corticofugal tract plasticity in hypertensive rats with cortical infarctions
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.09.002
Abstract: The approaches that facilitate white matter plasticity may prompt functional recovery after a stroke. The effects of different exercise methods on motor recovery in stroke rats have been investigated. However, it is not clear whether… read more here.
Keywords: rwe; group; tract; running wheel ... See more keywords
Crustal structure beneath Portugal from teleseismic Rayleigh Wave Ellipticity
Sign Up to like & getrecommendations! Published in 2017 at "Tectonophysics"
DOI: 10.1016/j.tecto.2017.06.001
Abstract: Up until now, Portugal lacked a countrywide shear velocity model sampling short length-scale crustal structure, which limits interpretations of seismicity and tectonics, and predictions of strong ground motion. In turn, such interpretations and predictions are… read more here.
Keywords: teleseismic rayleigh; rayleigh wave; rwe; wave ellipticity ... See more keywords
VP02 Real-World Evidence (RWE) And CADTH Pan-Canadian Oncology Drug Review
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Technology Assessment in Health Care"
DOI: 10.1017/s0266462318003367
Abstract: Introduction: The pan-Canadian Oncology Drug Review (pCODR) program was established by Canada's provincial and territorial Ministries of Health (except Quebec) to assess cancer drug therapies and make recommendations to guide drug reimbursement decisions. The pCODR… read more here.
Keywords: rwe; evidence; drug; drug review ... See more keywords
Real-world evidence use in assessments of cancer drugs by NICE
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Technology Assessment in Health Care"
DOI: 10.1017/s0266462320000434
Abstract: Objective To establish how real-world evidence (RWE) has been used to inform single technology appraisals (STAs) of cancer drugs conducted by the National Institute for Health and Care Excellence (NICE). Methods STAs published by NICE… read more here.
Keywords: cancer drugs; cancer; rwe; world evidence ... See more keywords
Key learnings from Institute for Clinical and Economic Review’s real-world evidence reassessment pilot
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Technology Assessment in Health Care"
DOI: 10.1017/s0266462322000162
Abstract: Abstract Health technology assessment (HTA) agencies are considering adopting a lifecycle approach to assessments to address uncertainties in the evidence base at launch and to revisit the clinical and economic value of therapies in a… read more here.
Keywords: rwe; institute clinical; evidence; world evidence ... See more keywords
Guest Editors’ Note on the Special Issue Real-World Evidence
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2022.2036992
Abstract: In pursuit of efficiency and speed in drug development, trialists are progressively pivoting on the use of real-world data (RWD) or real-world evidence (RWE), especially in the areas of high unmet medical need (Food and… read more here.
Keywords: rwe; propensity; world evidence; drug ... See more keywords
Real‐world experience versus clinical trials: pros and cons in psoriasis therapy evaluation
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Dermatology"
DOI: 10.1111/ijd.15644
Abstract: cons in psoriasis therapy evaluation Dear Editor, Safety and efficacy data rely on two ancillary sources, namely clinical trials and real-world experience. The two sources differ and complement one another in many aspects: for example,… read more here.
Keywords: safety; rwe; clinical trials; efficacy ... See more keywords
Real-World Evidence in Support of Oncology Product Registration: A Systematic Review of New Drug Application and Biologics License Application Approvals from 2015–2020
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-2639
Abstract: Real-world evidence (RWE) has garnered great interest to support registration of new therapies and label expansions by the United States Food and Drug Administration (FDA). Currently, practical insights on the design and analysis of regulatory-grade… read more here.
Keywords: application; oncology product; rwe; oncology ... See more keywords
The relevance of real-world data for the evaluation of neuropathic pain treatments.
Sign Up to like & getrecommendations! Published in 2022 at "Pain management"
DOI: 10.2217/pmt-2022-0057
Abstract: Treatment of neuropathic pain (NP) is challenging. Interest in real-world evidence (RWE) for benefit-risk assessments of NP treatments increases given the paucity of drugs showing efficacy in randomized controlled trials and restricted labels of available medicines.… read more here.
Keywords: rwe; relevance real; neuropathic pain; real world ... See more keywords
Integrating Real-World Evidence in the Regulatory Decision-Making Process: A Systematic Analysis of Experiences in the US, EU, and China Using a Logic Model
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.669509
Abstract: Real world evidence (RWE) and real-world data (RWD) are drawing ever-increasing attention in the pharmaceutical industry and drug regulatory authorities (DRAs) all over the world due to their paramount role in supporting drug development and… read more here.
Keywords: real world; rwe; regulatory decision; world ... See more keywords
Mapping Canadian Data Assets to Generate Real-World Evidence: Lessons Learned from Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration’s RWE Data Working Group
Sign Up to like & getrecommendations! Published in 2022 at "Current Oncology"
DOI: 10.3390/curroncol29030165
Abstract: Canadian provinces routinely collect patient-level data for administrative purposes. These real-world data (RWD) can be used to generate real-world evidence (RWE) to inform clinical care and healthcare policy. The CanREValue Collaboration is developing a framework… read more here.
Keywords: oncology; real world; world evidence; rwe ... See more keywords