Relaxin-3/RXFP3 signalling in mouse hypothalamus: no effect of RXFP3 activation on corticosterone, despite reduced presynaptic excitatory input onto paraventricular CRH neurons in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4575-z
Abstract: Relaxin-3/RXFP3 signalling is proposed to be involved in the neuromodulatory control of arousal- and stress-related neural circuits. Furthermore, previous studies in rats have led to the proposal that relaxin-3/RXFP3 signalling is associated with activation of… read more here.
Keywords: corticosterone; rxfp3; crh neurons; relaxin rxfp3 ... See more keywords
Overexpression of relaxin family peptide receptor 3 in Escherichia coli and characterization of its ligand binding properties
Sign Up to like & getrecommendations! Published in 2018 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2018.03.022
Abstract: Abstract Relaxin family peptide receptor 3 (RXFP3) is an A-class G protein-coupled receptor. It is implicated in the regulation of food intake and stress response upon activation by the neuropeptide relaxin-3. So far, preparation of… read more here.
Keywords: rxfp3; relaxin family; escherichia coli; family peptide ... See more keywords
Discovery and Characterization of the First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System.
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DOI: 10.1021/acs.jmedchem.2c00508
Abstract: The neuropeptide relaxin-3/RXFP3 system is involved in many important physiological processes such as stress responses, appetite control, and motivation for reward. To date, pharmacological studies of RXFP3 have been limited to peptide ligands. In this… read more here.
Keywords: discovery characterization; rxfp3 system; rxfp3; relaxin rxfp3 ... See more keywords
The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease
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DOI: 10.3390/ijms23084387
Abstract: During the aging process our body becomes less well equipped to deal with cellular stress, resulting in an increase in unrepaired damage. This causes varying degrees of impaired functionality and an increased risk of mortality.… read more here.
Keywords: relaxin receptor; receptor rxfp3; damage; rxfp3 ... See more keywords