Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXRα, RXRβ, and RXRγ.
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DOI: 10.1021/acs.jmedchem.2c01266
Abstract: The three retinoid X receptor subtypes (RXRα, RXRβ, RXRγ) exhibit critical regulatory roles in cell proliferation and differentiation, metabolism, and inflammation. Due to their importance in nuclear receptor signaling, RXRs are widely distributed and pan-RXR… read more here.
Keywords: rxr agonist; rxr rxr; new rxr; rxr ... See more keywords