Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13350
Abstract: There is no targeted therapy for KRAS proto‐oncogene, GTPase (KRAS)‐mutant metastatic colorectal cancer (mCRC) because the underlying mechanism remains obscure. Based on bioinformatic analysis, this study aims to elucidate a potential gene target for which… read more here.
Keywords: metastasis; ryanodine receptor; expression; colorectal cancer ... See more keywords
Synthesis, insecticidal evaluation and 3D-QSAR study of novel anthranilic diamide derivatives as potential ryanodine receptor modulators.
Sign Up to like & getrecommendations! Published in 2019 at "Pest management science"
DOI: 10.1002/ps.5213
Abstract: BACKGROUND Anthranilic diamide insecticides control lepidopteran pests through selectively binding and activating insect ryanodine receptors. In order to search for potential insecticides targeting the ryanodine receptors, a series of anthranilic diamide analogs including trifluoromethyl, nitro,… read more here.
Keywords: anthranilic diamide; ryanodine receptor; activity; receptor modulators ... See more keywords
Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_13
Abstract: Ryanodine receptor calcium release channels (RyRs) play central roles in controlling intracellular calcium concentrations in excitable and non-excitable cells. RyRs are located in the sarcoplasmic or endoplasmic reticulum, intracellular Ca2+ storage compartment, and release Ca2+… read more here.
Keywords: calcium release; receptor calcium; release channels; calcium ... See more keywords
Molecular cloning, characterization and mRNA expression of a ryanodine receptor gene from whitefly, Bemisia tabaci MED
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Asia-pacific Entomology"
DOI: 10.1016/j.aspen.2017.01.007
Abstract: Abstract The Bemisia tabaci (Gennadius) cryptic species complex comprises very destructive insect pests for agricultural crops worldwide. In China, the B. tabaci MED species (also known as biotype ‘Q’), has supplanted the MEAM1 species (biotype… read more here.
Keywords: tabaci med; tabaci; expression; bemisia tabaci ... See more keywords
Luminal addition of non-permeant Eu3+ interferes with luminal Ca2+ regulation of the cardiac ryanodine receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Bioelectrochemistry"
DOI: 10.1016/j.bioelechem.2019.107449
Abstract: Dysregulation of the cardiac ryanodine receptor (RYR2) by luminal Ca2+ has been implicated in a life-threatening, stress-induced arrhythmogenic disease. The mechanism of luminal Ca2+-mediated RYR2 regulation is under debate, and it has been attributed to… read more here.
Keywords: mechanism; luminal ca2; eu3; cardiac ryanodine ... See more keywords
A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsades de pointes ventricular arrhythmia.
Sign Up to like & getrecommendations! Published in 2017 at "Heart rhythm"
DOI: 10.1016/j.hrthm.2016.10.015
Abstract: BACKGROUND Ventricular fibrillation may be caused by premature ventricular contractions (PVCs) whose coupling intervals are read more here.
Keywords: torsades pointes; ca2 release; short coupled; ca2 ... See more keywords
High prevalence of rare ryanodine receptor type 1 variants in patients suffering from aneurysmatic subarachnoid hemorrhage: A pilot study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2017.06.029
Abstract: Subarachnoid hemorrhage (SAH) remains a challenging neurosurgical disease. The ryanodine receptor type 1 Ca2+ channel (RyR1) plays a crucial role in vasoconstriction and hemostasis. Mutations of the encoding gene, RYR1, are known to cause susceptibility… read more here.
Keywords: subarachnoid hemorrhage; ryr1; prevalence; receptor type ... See more keywords
Silence of ryanodine receptor gene decreases susceptibility to chlorantraniliprole in the oriental armyworm, Mythimna separata Walker.
Sign Up to like & getrecommendations! Published in 2018 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2018.03.012
Abstract: The ryanodine receptors of insects are the main target sites of diamide insecticides, which show highly selective insecticidal activity relative to toxicity in mammals and provide a novel option for managing lepidopteran pests. The oriental… read more here.
Keywords: separata walker; mythimna separata; ryanodine; armyworm mythimna ... See more keywords
Pyrrole-2 carboxamides - A novel class of insect ryanodine receptor activators.
Sign Up to like & getrecommendations! Published in 2021 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2021.104798
Abstract: The ryanodine receptor (RyR) is an intracellular calcium channel critical to the regulation of insect muscle contraction and the target site of diamide insecticides such as chlorantraniliprole, cyantraniliprole and flubendiamide. To-date, diamides are the only… read more here.
Keywords: receptor; ryanodine receptor; novel class; pyrrole carboxamides ... See more keywords
Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.10.011
Abstract: In cardiac myocytes Calmodulin (CaM) bound to the ryanodine receptor (RyR2) constitutes a large pool of total myocyte CaM, but the CaM-RyR2 affinity is reduced in pathological conditions. Knock-in mice expressing RyR2 unable to bind… read more here.
Keywords: cam; nuclear cam; ryr2; pathological cardiac ... See more keywords
Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability
Sign Up to like & getrecommendations! Published in 2020 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-020-0584-2
Abstract: Dendritic spines are postsynaptic domains that shape structural and functional properties of neurons. Upon neuronal activity, Ca 2+ transients trigger signaling cascades that determine the plastic remodeling of dendritic spines, which modulate learning and memory.… read more here.
Keywords: neuronal activity; ryanodine receptor; activity; remodeling dendritic ... See more keywords