Mapping Ryanodine Binding Sites in the Pore Cavity of Ryanodine Receptors.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.03.014
Abstract: Ryanodine (Ryd) irreversibly targets ryanodine receptors (RyRs), a family of intracellular calcium release channels essential for many cellular processes ranging from muscle contraction to learning and memory. Little is known of the atomistic details about… read more here.
Keywords: ryd; cavity; binding; ryanodine receptors ... See more keywords
Molecular Clustering of Skeletal and Cardiac Ryanodine Receptors
Sign Up to like & getrecommendations! Published in 2018 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927618006645
Abstract: Contraction of skeletal and cardiac muscles is triggered by transient increase of cytosolic Ca concentration. Such Ca transient is originated from the massive release of Ca stored in the sarco/endoplasmic reticulum (SR), via intracellular Ca… read more here.
Keywords: molecular clustering; skeletal cardiac; cardiac ryanodine; ryanodine receptors ... See more keywords
Enantioselectivity of 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) Atropisomers toward Ryanodine Receptors (RyRs) and Their Influences on Hippocampal Neuronal Networks.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental science & technology"
DOI: 10.1021/acs.est.7b04446
Abstract: Nineteen ortho-substituted PCBs are chiral and found enantioselectively enriched in ecosystems. Their differential actions on biological targets are not understood. PCB 95 (2,2',3,5',6-pentachlorobiphenyl), a chiral PCB of current environmental relevance, is among the most potent… read more here.
Keywords: hippocampal neuronal; pcb; ryanodine receptors; enantioselectivity pentachlorobiphenyl ... See more keywords
Effects of rogue ryanodine receptors on Ca2+ sparks in cardiac myocytes
Sign Up to like & getrecommendations! Published in 2018 at "Royal Society Open Science"
DOI: 10.1098/rsos.171462
Abstract: Ca2+ sparks and Ca2+ quarks, arising from clustered and rogue ryanodine receptors (RyRs), are significant Ca2+ release events from the junctional sarcoplasmic reticulum (JSR). Based on the anomalous subdiffusion of Ca2+ in the cytoplasm, a… read more here.
Keywords: ca2 sparks; cardiac myocytes; rogue ryanodine; effects rogue ... See more keywords
Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf4936
Abstract: Calcins are peptides from scorpion venom with the unique ability to cross cell membranes, gaining access to intracellular targets. Ryanodine Receptors (RyR) are intracellular ion channels that control release of Ca2+ from the endoplasmic and… read more here.
Keywords: cryo analysis; toxin; ryanodine receptors; subconductance ... See more keywords
Calmodulin variants associated with congenital arrhythmia impair selectivity for ryanodine receptors
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.1100992
Abstract: Among its many molecular targets, the ubiquitous calcium sensor protein calmodulin (CaM) recognizes and regulates the activity of ryanodine receptors type 1 (RyR1) and 2 (RyR2), mainly expressed in skeletal and cardiac muscle, respectively. Such… read more here.
Keywords: congenital arrhythmia; arrhythmia; variants associated; ryanodine receptors ... See more keywords
High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19020533
Abstract: Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, can produce ventricular… read more here.
Keywords: fat diet; ventricular arrhythmias; high fat; ryanodine receptors ... See more keywords