RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.12.002
Abstract: RNA-binding proteins (RBPs), in addition to their functions in cellular homeostasis, play important roles in lineage specification and maintaining cellular identity. Despite their diverse and essential functions, which touch on nearly all aspects of RNA… read more here.
Keywords: ddx5 inhibits; inhibits reprogramming; ddx5; rybp ... See more keywords
Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells
Sign Up to like & getrecommendations! Published in 2023 at "Open Biology"
DOI: 10.1098/rsob.220305
Abstract: RING1 and YY1 binding protein (RYBP) is primarily known to function as a repressor being a core component of the non-canonical polycomb repressive complexes 1 (ncPRC1s). However, several ncPRC1-independent functions of RYBP have also been… read more here.
Keywords: protein rybp; embryonic stem; mouse embryonic; plagl1 ... See more keywords
Polycomb protein RYBP facilitates super-enhancer activity
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine"
DOI: 10.1186/s10020-024-01006-3
Abstract: Polycomb proteins are conventionally known as global repressors in cell fate determination. However, recent observations have shown their involvement in transcriptional activation, the mechanisms of which need further investigation. Herein, multiple data from ChIP-seq, RNA-seq… read more here.
Keywords: polycomb protein; enhancer; protein rybp; rybp ... See more keywords
RYBP is important for cardiac progenitor cell development and sarcomere formation
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DOI: 10.1371/journal.pone.0235922
Abstract: We have previously established that epigenetic regulator RING1 and YY1 binding protein (RYBP) is required for the contractility of embryonic stem (ES) cell derived cardiomyocytes (CMCs), suggesting its essential role in contractility. In order to… read more here.
Keywords: rybp important; sarcomere formation; rybp; contractility ... See more keywords
Re-expression of circ_0043610 contributes to trophoblast dysfunction through the miR-558/RYBP pathway in preeclampsia.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine journal"
DOI: 10.1507/endocrj.ej22-0153
Abstract: An increasing number of data have shown the pathogenesis of preeclampsia (PE) involves circular RNA (circRNA). The study aims to investigate the function and the potential mechanism of circ_0043610 in PE. The study was performed… read more here.
Keywords: circ 0043610; cell; mir 558; expression circ ... See more keywords
Unveiling the Binding between the Armadillo-Repeat Domain of Plakophilin 1 and the Intrinsically Disordered Transcriptional Repressor RYBP
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DOI: 10.3390/biom14050561
Abstract: Plakophilin 1 (PKP1), a member of the p120ctn subfamily of the armadillo (ARM)-repeat-containing proteins, is an important structural component of cell–cell adhesion scaffolds although it can also be ubiquitously found in the cytoplasm and the… read more here.
Keywords: repeat; pkp1; intrinsically disordered; plakophilin ... See more keywords
RYBP Sensitizes Cancer Cells to PARP Inhibitors by Regulating ATM Activity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911764
Abstract: Ring1 and YY1 Binding Protein (RYBP) is a member of the non-canonical polycomb repressive complex 1 (PRC1), and like other PRC1 members, it is best described as a transcriptional regulator. Previously, we showed that RYBP,… read more here.
Keywords: cancer; dna damage; rybp; cancer cells ... See more keywords