Dose-dependence in acquisition of drug tolerant phenotype and high RYK expression as a mechanism of osimertinib tolerance in lung cancer.
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DOI: 10.1016/j.lungcan.2021.02.017
Abstract: OBJECTIVE Emergence of acquired resistance is almost inevitable during EGFR-tyrosine kinase inhibitor therapy for non-small-cell lung cancer (NSCLC) harboring EGFR mutations. Drug tolerance, a reversible state of drug insensitivity in the early phases of tyrosine… read more here.
Keywords: tolerance; drug; drug tolerance; lung cancer ... See more keywords