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   Articles with "ryr" as a keyword



Red yeast rice prevents atherosclerosis through regulating inflammatory signaling pathways

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recommendations! Published in 2017 at "Chinese Journal of Integrative Medicine"

DOI: 10.1007/s11655-017-2416-x

Abstract: ObjectiveTo observe the effects of red yeast rice (RYR) on blood lipid levels, aortic atherosclerosis (AS), and plaque stability in apolipoprotein E gene knockout (ApoE-/-) mice.MethodsTwenty-four ApoE-/- mice were fed with a high-fat diet starting… read more here.

Keywords: signaling pathways; red yeast; group; yeast rice ... See more keywords

Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study

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recommendations! Published in 2025 at "Toxicological Research"

DOI: 10.1007/s43188-025-00297-w

Abstract: Red yeast rice (RYR) is commonly used as colouring and flavouring agent in foods throughout East Asia. RYR contains monacolin K, a compound known to lower blood lipids level, which has led to its use… read more here.

Keywords: red yeast; rice; day feeding; yeast rice ... See more keywords

Size Matters: Ryanodine Receptor Cluster Size Heterogeneity Potentiates Calcium Waves.

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recommendations! Published in 2019 at "Biophysical journal"

DOI: 10.1016/j.bpj.2018.12.017

Abstract: Ryanodine receptors (RyRs) mediate calcium (Ca)-induced Ca release and intracellular Ca homeostasis. In a cardiac myocyte, RyRs group into clusters of variable size from a few to several hundred RyRs, creating a spatially nonuniform intracellular… read more here.

Keywords: ryr clusters; ryr cluster; ryr; size ... See more keywords

Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 genome modification in Drosophila.

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recommendations! Published in 2017 at "Insect biochemistry and molecular biology"

DOI: 10.1016/j.ibmb.2017.06.013

Abstract: Diamide insecticides are used widely against lepidopteran pests, acting as potent activators of insect Ryanodine Receptors (RyRs) and thus inducing muscle contraction and eventually death. However, resistant phenotypes have recently evolved in the field, associated… read more here.

Keywords: diamide resistance; crispr cas9; ryr; resistance ... See more keywords

Three-dimensional visualization of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads

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recommendations! Published in 2022 at "Philosophical Transactions of the Royal Society B: Biological Sciences"

DOI: 10.1098/rstb.2021.0316

Abstract: Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular machinery of intracellular calcium signalling in cardiomyocytes. While a range of optical super-resolution microscopy techniques have revealed the nanoscale structure of these clusters, the… read more here.

Keywords: ryr; molecular scale; microscopy; ryanodine receptor ... See more keywords

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

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recommendations! Published in 2022 at "eLife"

DOI: 10.1101/2022.02.18.481024

Abstract: Ryanodine Receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that “dispersion” of RyR clusters disrupts Ca2+ homeostasis during heart failure (HF) (Kolstad et al., eLife, 2018). Here, we investigated whether prolonged β-adrenergic… read more here.

Keywords: ryr; dispersion; adrenergic stimulation; pathology ... See more keywords

Ryanodine Receptor Type 2 Plays a Role in the Development of Cardiac Fibrosis under Mechanical Stretch Through TGFβ-1.

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recommendations! Published in 2017 at "International heart journal"

DOI: 10.1536/ihj.16-572

Abstract: Ryanodine receptor type 2 (RyR-2), the main Ca2+ release channel from sarcoplasmic reticulum in cardiomyocytes, plays a vital role in the regulation ofmyocardial contractile function and cardiac hypertrophy. However, the role of RyR-2 in cardiac… read more here.

Keywords: development cardiac; fibrosis; cardiac fibrosis; ryr ... See more keywords

Red Yeast Rice for Hyperlipidemia: A Meta-Analysis of 15 High-Quality Randomized Controlled Trials

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2021.819482

Abstract: Background: RYR is a commonly used lipid-lowering dietary supplements in Asian and European countries, showing considerable benefits and low toxicity. This quantitative study aims to present high-quality evidence regarding the efficacy and safety of RYR… read more here.

Keywords: ryr; quality randomized; controlled trials; hyperlipidemia ... See more keywords

The Ryanodine Receptor as a Sensor for Intracellular Environments in Muscles

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms221910795

Abstract: The ryanodine receptor (RyR) is a Ca2+ release channel in the sarcoplasmic reticulum of skeletal and cardiac muscles and plays a key role in excitation–contraction coupling. The activity of the RyR is regulated by the… read more here.

Keywords: receptor sensor; ryr; intracellular environments; ryanodine receptor ... See more keywords

The Impact of Red Yeast Rice Extract Use on the Occurrence of Muscle Symptoms and Liver Dysfunction: An Update from the Adverse Event Reporting Systems and Available Meta-Analyses

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recommendations! Published in 2024 at "Nutrients"

DOI: 10.3390/nu16030444

Abstract: Red yeast rice (RYR) has a cholesterol-lowering effect due to the presence of bioactive components (monacolins, mainly monacolin K) that act by inhibiting the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. The European Food Safety… read more here.

Keywords: meta analyses; use; muscle; ryr ... See more keywords