Red yeast rice prevents atherosclerosis through regulating inflammatory signaling pathways
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-017-2416-x
Abstract: ObjectiveTo observe the effects of red yeast rice (RYR) on blood lipid levels, aortic atherosclerosis (AS), and plaque stability in apolipoprotein E gene knockout (ApoE-/-) mice.MethodsTwenty-four ApoE-/- mice were fed with a high-fat diet starting… read more here.
Keywords: signaling pathways; red yeast; group; yeast rice ... See more keywords
Size Matters: Ryanodine Receptor Cluster Size Heterogeneity Potentiates Calcium Waves.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.12.017
Abstract: Ryanodine receptors (RyRs) mediate calcium (Ca)-induced Ca release and intracellular Ca homeostasis. In a cardiac myocyte, RyRs group into clusters of variable size from a few to several hundred RyRs, creating a spatially nonuniform intracellular… read more here.
Keywords: ryr clusters; ryr cluster; ryr; size ... See more keywords
Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 genome modification in Drosophila.
Sign Up to like & getrecommendations! Published in 2017 at "Insect biochemistry and molecular biology"
DOI: 10.1016/j.ibmb.2017.06.013
Abstract: Diamide insecticides are used widely against lepidopteran pests, acting as potent activators of insect Ryanodine Receptors (RyRs) and thus inducing muscle contraction and eventually death. However, resistant phenotypes have recently evolved in the field, associated… read more here.
Keywords: diamide resistance; crispr cas9; ryr; resistance ... See more keywords
Three-dimensional visualization of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads
Sign Up to like & getrecommendations! Published in 2022 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2021.0316
Abstract: Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular machinery of intracellular calcium signalling in cardiomyocytes. While a range of optical super-resolution microscopy techniques have revealed the nanoscale structure of these clusters, the… read more here.
Keywords: ryr; molecular scale; microscopy; ryanodine receptor ... See more keywords
Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.02.18.481024
Abstract: Ryanodine Receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that “dispersion” of RyR clusters disrupts Ca2+ homeostasis during heart failure (HF) (Kolstad et al., eLife, 2018). Here, we investigated whether prolonged β-adrenergic… read more here.
Keywords: ryr; dispersion; adrenergic stimulation; pathology ... See more keywords
Ryanodine Receptor Type 2 Plays a Role in the Development of Cardiac Fibrosis under Mechanical Stretch Through TGFβ-1.
Sign Up to like & getrecommendations! Published in 2017 at "International heart journal"
DOI: 10.1536/ihj.16-572
Abstract: Ryanodine receptor type 2 (RyR-2), the main Ca2+ release channel from sarcoplasmic reticulum in cardiomyocytes, plays a vital role in the regulation ofmyocardial contractile function and cardiac hypertrophy. However, the role of RyR-2 in cardiac… read more here.
Keywords: development cardiac; fibrosis; cardiac fibrosis; ryr ... See more keywords
Red Yeast Rice for Hyperlipidemia: A Meta-Analysis of 15 High-Quality Randomized Controlled Trials
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.819482
Abstract: Background: RYR is a commonly used lipid-lowering dietary supplements in Asian and European countries, showing considerable benefits and low toxicity. This quantitative study aims to present high-quality evidence regarding the efficacy and safety of RYR… read more here.
Keywords: ryr; quality randomized; controlled trials; hyperlipidemia ... See more keywords
The Ryanodine Receptor as a Sensor for Intracellular Environments in Muscles
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910795
Abstract: The ryanodine receptor (RyR) is a Ca2+ release channel in the sarcoplasmic reticulum of skeletal and cardiac muscles and plays a key role in excitation–contraction coupling. The activity of the RyR is regulated by the… read more here.
Keywords: receptor sensor; ryr; intracellular environments; ryanodine receptor ... See more keywords