Size Matters: Ryanodine Receptor Cluster Size Heterogeneity Potentiates Calcium Waves.
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DOI: 10.1016/j.bpj.2018.12.017
Abstract: Ryanodine receptors (RyRs) mediate calcium (Ca)-induced Ca release and intracellular Ca homeostasis. In a cardiac myocyte, RyRs group into clusters of variable size from a few to several hundred RyRs, creating a spatially nonuniform intracellular… read more here.
Keywords: ryr clusters; ryr cluster; ryr; size ... See more keywords
Computational Model of Calcium Signaling in Cardiac Atrial Cells at the Submicron Scale
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.01760
Abstract: In cardiac cells, calcium is the mediator of excitation-contraction coupling. Dysfunctions in calcium handling have been identified as the origin of some cardiac arrhythmias. In the particular case of atrial myocytes, recent available experimental data… read more here.
Keywords: model calcium; computational model; ryr cluster; model ... See more keywords