Limiting RyR2 open time prevents Alzheimer's disease-related deficits in the 3xTG-AD mouse model.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuroscience research"
DOI: 10.1002/jnr.24936
Abstract: Increasing evidence suggests that Alzheimer's disease (AD) progression is driven by a vicious cycle of soluble β-amyloid (Aβ)-induced neuronal hyperactivity. Thus, breaking this vicious cycle by suppressing neuronal hyperactivity may represent a logical approach to… read more here.
Keywords: open time; limiting ryr2; mouse model; ryr2 open ... See more keywords
Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108169
Abstract: SUMMARY Neuronal hyperactivity is an early primary dysfunction in Alzheimer’s disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed anti-AD therapeutic agents are lacking. Here we define a previously unknown mode of ryanodine… read more here.
Keywords: hyperactivity; open time; neuronal hyperactivity; ryr2 open ... See more keywords