Elevated S100A4 in asthmatics and an allergen‐induced mouse asthma model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28245
Abstract: The elevated S100A4 level has been found in some inflammatory diseases. However, the expression and role of S100A4 in asthma is unknown. The expression of S100A4 in induced sputum and plasma from healthy control and… read more here.
Keywords: elevated s100a4; s100a4; allergen induced; model ... See more keywords
Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81611-y
Abstract: S100A4, a member of the S100 family of multifunctional calcium-binding proteins, participates in several physiological and pathological processes. In this study, we demonstrate that S100A4 expression is robustly induced in differentiating fiber cells of the… read more here.
Keywords: mouse lens; lens induces; s100a4; s100a4 mouse ... See more keywords
Clinicopathological and prognostic value of S100A4 expression in non-small cell lung cancer: a meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20201710
Abstract: Abstract Background: Numerous published studies have shown that S100A4 is frequently overexpressed in various human cancers. However, the association between S100A4 expression and prognosis or clinicopathological parameters in non-small cell lung cancer (NSCLC) remains unclear.… read more here.
Keywords: s100a4 expression; association s100a4; s100a4; expression ... See more keywords
The function of S100A4 in pulmonary disease: A review
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000033466
Abstract: S100 protein family, which represents 25 relatively small calcium binding proteins, is involved in many intracellular and/or extracellular processes, including differentiation, apoptosis, migration/invasion, Ca2+ homeostasis, inflammation, and tissue repair. As an important member, S100A4 was… read more here.
Keywords: lung cancer; s100a4; pulmonary disease; function ... See more keywords
Abstract 1616: S100A4 blockage alleviates agonistic anti-CD137 antibody induced liver pathology without disruption of anti-tumor immunity
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1616
Abstract: Liver-related autoimmune toxicities triggered by anti-CD137 agonist antibodies have greatly limited their use in clinic applications. Here we found that anti-CD137 monoclonal antibody (mAb) treatment in mice induced the infiltration of a large number of… read more here.
Keywords: anti cd137; s100a4; tumor immunity; antibody ... See more keywords
Abstract 2948: A humanized therapeutic antibody against S100A4 as a novel immune modulator and an inhibitor of cancer metastasis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2948
Abstract: Widespread cancer metastasis still contributes to ~ 90% of cancer-related deaths, and limited progress has been made in treating the metastatic disease. S100A4 is a highly conserved protein and has been demonstrated to promote cancer… read more here.
Keywords: novel immune; cancer metastasis; s100a4; cancer ... See more keywords
Improvements in left ventricular regional and global systolic function following treatment with S100A4-shRNA after myocardial infarction in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Quantitative imaging in medicine and surgery"
DOI: 10.21037/qims.2019.05.25
Abstract: Background S100A4 plays a vital role in cardiac fibrosis after myocardial infarction (MI), but its effects on myocardial mechanics and remodeling are unknown. We hypothesized that regional and global left ventricular (LV) systolic function as… read more here.
Keywords: systolic function; s100a4 shrna; ste; s100a4 ... See more keywords
Quantitative shear wave elastography in primary invasive breast cancers, based on collagen-S100A4 pathology, indicates axillary lymph node metastasis.
Sign Up to like & getrecommendations! Published in 2020 at "Quantitative imaging in medicine and surgery"
DOI: 10.21037/qims.2020.02.18
Abstract: Background The purpose of this study was to evaluate the value of quantitative shear wave elastography (SWE) in indicating the axillary lymph node metastasis (LNM) of invasive breast cancers (IBCs) and to investigate if S100A4… read more here.
Keywords: collagen; s100a4; quantitative shear; pathology ... See more keywords
Cell non-autonomous functions of S100a4 drive fibrotic tendon healing
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.45342
Abstract: Identification of pro-regenerative approaches to improve tendon healing is critically important as the fibrotic healing response impairs physical function. In the present study we tested the hypothesis that S100a4 haploinsufficiency or inhibition of S100a4 signaling… read more here.
Keywords: cell non; fibrotic tendon; tendon healing; tendon ... See more keywords