Biological therapy downregulates the heterodimer S100A8/A9 (calprotectin) expression in psoriatic patients
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1147-6
Abstract: The pathophysiology of psoriasis is very complex and involves an interplay between immune cells and keratinocytes. The keratinocyte production of calprotectin (S100A8/A9), induced by the inflammatory psoriatic milieu, may be involved in initiating immune cell… read more here.
Keywords: biological therapy; psoriatic patients; s100a8; expression ... See more keywords
High expression of S100 calgranulin genes in peripheral blood mononuclear cells from patients with Takayasu arteritis
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2018.11.033
Abstract: Background: Toll‐like receptors (TLR) 1 to 4 are highly expressed in aorta. Activation of TLR4 causes transmural arteritis in Human temporal artery‐SCID chimera model. Neither TLR‐4 nor its ligands have been studied in TA patients… read more here.
Keywords: blood mononuclear; healthy controls; s100a8; peripheral blood ... See more keywords
Effects of Platycodin D on S100A8/A9-induced inflammatory response in murine mammary carcinoma 4T1 cells.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2018.12.008
Abstract: Activation of the inflammatory signaling pathway is the most vital part of the pre-metastatic events of breast cancer. Platycodin D (PlaD) shows favorable pharmacological activities in anti-inflammatory and anti-tumor effect. The main purpose of this… read more here.
Keywords: carcinoma 4t1; 4t1 cells; s100a8 induced; mammary carcinoma ... See more keywords
Calcium-Dependent S100A8 Amyloid Fibril Formation via S100A1-Mediated Transient Interaction
Sign Up to like & getrecommendations! Published in 2025 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.5c00086
Abstract: The S100 family consists of calcium-binding proteins that are largely known for their contribution to neuroinflammatory processes. These proteins are associated with various cardiac and neurological functions as well as related diseases. A few S100… read more here.
Keywords: s100a1; s100a8 amyloid; calcium; s100a8 ... See more keywords
S100A8/A9 and S100A9 reduce acute lung injury
Sign Up to like & getrecommendations! Published in 2017 at "Immunology and Cell Biology"
DOI: 10.1038/icb.2017.2
Abstract: S100A8 and S100A9 are myeloid cell‐derived proteins that are elevated in several types of inflammatory lung disorders. Pro‐ and anti‐inflammatory properties are reported and these proteins are proposed to activate TLR4. S100A8 and S100A9 can… read more here.
Keywords: lung injury; s100a8; s100a9; acute lung ... See more keywords
Stress-induced release of the S100A8/A9 alarmin is elevated in coronary artery disease patients with impaired cortisol response
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17586-6
Abstract: Psychological stress is thought to be an important trigger of cardiovascular events, yet the involved pathways and mediators are largely unknown. Elevated systemic levels of the pro-inflammatory alarmin S100A8/A9 correlate with poor prognosis in coronary… read more here.
Keywords: response; coronary artery; s100a8; stress ... See more keywords
Leukemia cells remodel bone marrow stromal cells to generate a protumoral microenvironment via the S100A8-NOX2-ROS signaling pathway
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-01711-x
Abstract: The bone marrow microenvironment (BMM) plays a crucial role in the pathogenesis and progression of acute myeloid leukemia (AML). AML cells can modify the BMM to establish a more favorable environment for their survival. However,… read more here.
Keywords: aml; culture; s100a8; bone marrow ... See more keywords
S100A8/A9 as a prognostic biomarker in lung transplantation.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical transplantation"
DOI: 10.1111/ctr.15006
Abstract: OBJECTIVES S100A8/A9 is a damage-associated molecule that augments systemic inflammation. However, its role in the acute phase after lung transplantation (LTx) remains elusive. This study aimed to determine S100A8/A9 levels after lung transplantation (LTx) and… read more here.
Keywords: lung transplantation; s100a8; s100a8 levels; survival ... See more keywords
AB0071 SERUM S100A8/A9 (CALPROTECTIN) IN FAMILIAL MEDITERRANEAN FEVER DOES NOT CORRELATE WITH DISEASE ACTIVITY
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.2669
Abstract: Background Familial Mediterranean Fever (FMF) is caused by mutations in MEFV. The protein product pyrin is expressed in monocytes, neutrophils and eosinophils. Acute inflammatory attacks are accompanied by a dramatic hepatic acute phase response. S100A8/A9… read more here.
Keywords: serum s100a8; none declared; disease; s100a8 ... See more keywords
S100A8 as a Promising Biomarker and Oncogenic Immune Protein in the Tumor Microenvironment: An Integrative Pancancer Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/6947652
Abstract: Background S100 Calcium Binding Protein A8 (S100A8) is beneficial for cancer immunotherapy. However, the processes underlying its therapeutic potential have not been completely studied. Methods The Cancer Genome Atlas provides raw data on 33 different… read more here.
Keywords: biomarker; s100a8; cancer immunotherapy; tumor ... See more keywords
Abstract 2127: Efficacy of monoclonal antibodies against pathogenic S100A8/9 in myelodysplasia and leukemia models
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-2127
Abstract: Myelodysplastic syndromes (MDS); chronic myelomonocytic leukemias (CMML) and acute myeloid leukemia (AML) are characterized by a block in normal differentiation of stem and progenitor cells that leads to cytopenias. The diseased marrow microenvironment is characterized… read more here.
Keywords: antibodies pathogenic; efficacy monoclonal; pathogenic s100a8; leukemia ... See more keywords