S100A9 Derived from Chemoembolization‐Induced Hypoxia Governs Mitochondrial Function in Hepatocellular Carcinoma Progression
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202206
Abstract: Transarterial chemoembolization (TACE) is the major treatment for advanced hepatocellular carcinoma (HCC), but it may cause hypoxic environment, leading to rapid progression after treatment. Here, using high‐throughput sequencing on different models, S100 calcium binding protein… read more here.
Keywords: chemoembolization; hepatocellular carcinoma; hcc; s100a9 ... See more keywords
The prognostic value of S100A calcium binding protein family members in predicting severe forms of COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Inflammation Research"
DOI: 10.1007/s00011-022-01545-7
Abstract: Background Excessive inflammation has been implicated in the immunopathogenesis of coronavirus disease 2019 (COVID-19). In the current study, the involvement of S100 calcium binding protein S100A4, S100A9, and S100A10 in the inflammatory settings of COVID-19… read more here.
Keywords: s100a9; binding protein; covid; s100a10 ... See more keywords
Induction of S100A9 homodimer formation in vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.086
Abstract: We show here that increased S100A8 and S100A9 protein expression is induced in spleen of animals with active inflammation or with inoculated tumors. In tumor bearing animals an increased expression was also detected in the… read more here.
Keywords: s100a9 homodimers; homodimer formation; induction s100a9; formation vivo ... See more keywords
Metastatic Colon Cancer Treatment Using S100A9-Targeted Cowpea Mosaic Virus Nanoparticles.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00873
Abstract: Peritoneal metastases (PMs) occur due to the metastasis of gynecological and gastrointestinal cancers such as ovarian, colon, pancreatic, or gastric tumors. PM outgrowth is often fatal, and patients with PMs have a median survival of… read more here.
Keywords: cowpea mosaic; s100a9; mosaic virus; treatment ... See more keywords
S100A8/A9 and S100A9 reduce acute lung injury
Sign Up to like & getrecommendations! Published in 2017 at "Immunology and Cell Biology"
DOI: 10.1038/icb.2017.2
Abstract: S100A8 and S100A9 are myeloid cell‐derived proteins that are elevated in several types of inflammatory lung disorders. Pro‐ and anti‐inflammatory properties are reported and these proteins are proposed to activate TLR4. S100A8 and S100A9 can… read more here.
Keywords: lung injury; s100a8; s100a9; acute lung ... See more keywords
S100A9 as a novel diagnostic and prognostic biomarker in human gastric cancer
Sign Up to like & getrecommendations! Published in 2020 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2020.1737883
Abstract: Abstract Objective: The morbidity and mortality of gastric cancer (GC) is high, but there are lack of the biomarkers for early diagnosis and progression of GC. We aimed to identify a novel biomarker for the… read more here.
Keywords: s100a9 novel; gastric cancer; prognosis; biomarker ... See more keywords
S100a9 knockout contributes to neuroprotection and functional improvement after traumatic brain injury.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurotrauma"
DOI: 10.1089/neu.2018.6170
Abstract: S100a9, a proinflammatory protein, has been shown to be involved in the development of neuroinflammatory disorders and neurodegenerative diseases. Upregulation of S100a9 in the brain during acute brain injury has been proposed to be associated… read more here.
Keywords: traumatic brain; s100a9; tbi; brain injury ... See more keywords
Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-17-0192
Abstract: In mouse multiple myeloma, treatment with the small molecule ABR-238901 interfered with calcium-binding protein S100A9, affected cytokine secretion and angiogenesis, and reduced tumor load. Results improved further when ABR-238901 was delivered in combination with the… read more here.
Keywords: angiogenesis; multiple myeloma; abr 238901; s100a9 ... See more keywords
S100A9 Links Inflammation and Repair in Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/circresaha.120.315865
Abstract: Supplemental Digital Content is available in the text. Rationale: The alarmin S100A9 has been identified as a potential therapeutic target in myocardial infarction. Short-term S100A9 blockade during the inflammatory phase post-myocardial infarction inhibits systemic and… read more here.
Keywords: term; cardiac function; s100a9 blockade; s100a9 ... See more keywords
SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019001963
Abstract: SETD2, the histone H3 lysine 36 methyltransferase, previously identified by us, plays an important role in the pathogenesis of hematologic malignancies, but its role in myelodysplastic syndromes (MDSs) has been unclear. In this study, low… read more here.
Keywords: setd2 deficiency; s100a9; mds associated; mds ... See more keywords
S100A9 up-regulated by IFNGR signaling blockade functions as a novel GvHD suppressor without compromising GvL in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021012687
Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for both malignant and nonmalignant hematologic disorders. However, graft-versus-host disease (GvHD) and malignant relapse limit its therapeutic success. We previously demonstrated that blockade of interferon-gamma… read more here.
Keywords: ifngr signaling; s100a9; gvhd; gvhd suppressor ... See more keywords