G2-S16 dendrimer as a candidate for a microbicide to prevent HIV-1 infection in women.
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DOI: 10.1039/c7nr03034g
Abstract: Unprotected heterosexual intercourse is the first route for sustaining the global spread of human immunodeficiency virus type 1 (HIV-1), being responsible for 80% of new HIV-1 infections in the world. The presence of inflammation in… read more here.
Keywords: hiv infection; s16 dendrimer; hiv; candidate ... See more keywords
G2-S16 dendrimer microbicide does not interfere with the vaginal immune system
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-019-0496-9
Abstract: It is essential that prophylactic drugs do not interfere with the normal function of the immune system. The use of nanoparticles as vaginal microbicides is a promising prevention strategy against sexually transmitted infections. With that… read more here.
Keywords: dendrimer; immune system; s16 dendrimer; dendrimer microbicide ... See more keywords
Safety and efficacy of G2-S16 dendrimer as microbicide in healthy human vaginal tissue explants
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DOI: 10.1186/s12951-022-01350-8
Abstract: Background The absence of an effective treatment and vaccine in HIV-1 pandemic place preventive strategies such as safety and effective microbicide development as a central therapeutic approach to control HIV-1 pandemic nowadays. Results Studies of… read more here.
Keywords: microbicide; vaginal tissue; s16 dendrimer; tissue explants ... See more keywords
Safety of G2-S16 Polyanionic Carbosilane Dendrimer as Possible HIV-1 Vaginal Microbicide
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DOI: 10.3390/ijms23052565
Abstract: The UNAIDS objective for 2020 was 500,000 new HIV-1 infections per year; however, the latest annual reported data confirmed 1.7 million new HIV-1 infections in that year. Those data evidences the need for new prevention… read more here.
Keywords: vaginal microbicide; safety; dendrimer; carbosilane dendrimer ... See more keywords