Sphingosine‐1‐phosphate‐lyase deficiency affects glucose metabolism in a way that abets oncogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13300
Abstract: Sphingosine‐1‐phosphate (S1P), a bioactive signaling lipid, is involved in several vital processes, including cellular proliferation, survival and migration, as well as neovascularization and inflammation. Its critical role in the development and progression of cancer is… read more here.
Keywords: metabolism; s1p; glucose metabolism; lyase ... See more keywords
Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104452
Abstract: SPHK1 (sphingosine kinase-1) catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P), is found to be highly expressed in solid tumors. Here, extracellular vesicles (EVs) are identified as the key transporters of SPHK1 to the tumor… read more here.
Keywords: tumor; tumor microenvironment; s1p; sphingosine ... See more keywords
Enhanced phosphorylation of sphingosine and ceramide sustains the exuberant proliferation of endothelial progenitors in Kaposi sarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2ma0817-312r
Abstract: Endothelial colony‐forming cells (ECFCs), a unique endothelial stem cell population, are highly increased in the blood of Kaposi sarcoma (KS) patients. KS‐derived ECFCs (KS‐ECFCs) are also endowed with increased proliferative and vasculogenic potential, thus suggesting… read more here.
Keywords: kaposi sarcoma; proliferation; sphingosine; s1p ... See more keywords
S1P Signaling in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-35582-1_7
Abstract: Sphingosine-1-phosphate (S1P), together with other phosphosphingolipids, has been found to regulate complex cellular function in the tumor microenvironment (TME) where it acts as a signaling molecule that participates in cell-cell communication. S1P, through intracellular and… read more here.
Keywords: signaling tumor; s1p signaling; s1p; tumor microenvironment ... See more keywords
Sphingosine-1-phosphate is involved in inflammatory reactions in patients with Graves’ orbitopathy
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation Research"
DOI: 10.1007/s00011-017-1037-3
Abstract: ObjectiveGraves’ orbitopathy (GO) is initiated by excessive amount of various inflammatory mediators produced by orbital fibroblasts. This study aimed to assess the crucial role of sphingosine-1-phosphate (S1P) in the inflammatory process of GO.MethodsOrbital adipose/connective tissue… read more here.
Keywords: s1p; sphingosine phosphate; inflammatory process; orbital fibroblasts ... See more keywords
Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1599-x
Abstract: Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions. In this study, we characterized the retinas of Sphk1 knockout (KO) mice by… read more here.
Keywords: limiting membrane; adherens junctions; outer limiting; s1p ... See more keywords
Modulation of sphingosine-1-phosphate in inflammatory bowel disease.
Sign Up to like & getrecommendations! Published in 2017 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2017.03.007
Abstract: Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, involve an inappropriate immune reaction in the digestive tract, causing a variety of disabling symptoms. The advent of monoclonal antibodies (anti-tumor necrosis factor, anti-integrin, anti-interleukin… read more here.
Keywords: inflammatory bowel; disease; sphingosine phosphate; ulcerative colitis ... See more keywords
Sphingosine 1-phosphate escapes the Catch-22 of sepsis prevention and mitigation therapies
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102952
Abstract: Sepsis is defined as life-threatening organ dysfunction as a consequence of a dysregulated host immune response to infection and is the leading cause of mortality across the globe [1]. Septic organ dysfunction leads to a… read more here.
Keywords: sepsis; sphingosine phosphate; phosphate escapes; s1p ... See more keywords
Preventive preclinical efficacy of intravenously administered sphingosine-1-phosphate (S1P) in strengthening hypoxia adaptive responses to acute and sub-chronic hypobaric hypoxia.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172877
Abstract: Sphingosine-1-phosphate (S1P) is emerging as a hypoxia responsive bio-lipid; systemically raised levels of S1P are proposed to have potential hypoxia pre-conditioning effects. The study aims to evaluate the hypoxia pre-conditioning efficacy of exogenously administered S1P… read more here.
Keywords: sub chronic; hypobaric hypoxia; s1p; hypoxia ... See more keywords
β1-Blockade Prevents Post-Ischemic Myocardial Decompensation Via β3AR-Dependent Protective Sphingosine-1 Phosphate Signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.05.020
Abstract: BACKGROUND Although β-blockers increase survival in patients with heart failure (HF), the mechanisms behind this protection are not fully understood, and not all patients with HF respond favorably to them. We recently showed that, in cardiomyocytes,… read more here.
Keywords: sphingosine phosphate; s1p; meto; 3ar dependent ... See more keywords
Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.02.009
Abstract: The past two decades of intense research have revealed a key role of the sphingolipid molecule sphingosine 1-phosphate (S1P) in regulating multiple physiological and pathophysiological processes including cell proliferation and survival, cell migration, inflammatory mediator… read more here.
Keywords: treatment; inflammatory diseases; inflammatory; autoimmune inflammatory ... See more keywords