S1P Signaling in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-35582-1_7
Abstract: Sphingosine-1-phosphate (S1P), together with other phosphosphingolipids, has been found to regulate complex cellular function in the tumor microenvironment (TME) where it acts as a signaling molecule that participates in cell-cell communication. S1P, through intracellular and… read more here.
Keywords: signaling tumor; s1p signaling; s1p; tumor microenvironment ... See more keywords
The role of sphingosine-1-phosphate signaling pathway in cementocyte mechanotransduction.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.01.003
Abstract: Iatrogenic external root resorption can become a serious pathological condition with clinical tooth movement. Little is known regarding how cementum responds to mechanical loading in contrast to bone, especially under compressive stress. In the field… read more here.
Keywords: sphingosine phosphate; compressive stress; s1p signaling; mechanotransduction ... See more keywords
Finding a Way Out: S1P Signaling and Immune Cell Migration.
Sign Up to like & getrecommendations! Published in 2020 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-081519-083952
Abstract: The signaling lipid sphingosine 1-phosphate (S1P) plays critical roles in an immune response. Drugs targeting S1P signaling have been remarkably successful in treatment of multiple sclerosis, and they have shown promise in clinical trials for… read more here.
Keywords: immune cell; finding way; s1p signaling; s1p ... See more keywords
Inhibition of SphK1/S1P Signaling Pathway Alleviates Fibrosis and Inflammation of Rat Myocardium after Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/5985375
Abstract: Objective The sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P) signaling pathway is involved in fibrosis and inflammatory responses of myocardial tissue after myocardial infarction (MI). The purpose of our study was to explore the role of SphK1/S1P… read more here.
Keywords: signaling pathway; pf543; myocardial infarction; s1p signaling ... See more keywords
Abstract P1-09-07: Sub-group of PIK3CA WT breast cancer patients have hyperactive S1P signaling tumor cells responsive to PIK3-inhibitors: Functional signaling profile test identifies new patient group who may benefit from PIK3-targeted therapies
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs19-p1-09-07
Abstract: Background: Less than 20% of PI3KCA mutated late stage breast cancer patients achieved an objective response in a Phase III clinical trial with alpelisib, a recently approved PIK3CA inhibitor. This suggests biological factors other than… read more here.
Keywords: s1p signaling; tumor cells; cancer; breast cancer ... See more keywords