Exercise activates the hypothalamic S1PR1–STAT3 axis through the central action of interleukin 6 in mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26818
Abstract: Hypothalamic sphingosine‐1‐phosphate receptor 1 (S1PR1), the G protein–coupled receptor 1 of sphingosine‐1‐phosphate, has been described as a modulator in the control of energy homeostasis in rodents. However, this mechanism is still unclear. Here, we evaluate… read more here.
Keywords: stat3 axis; mice; s1pr1; exercise ... See more keywords
Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.035
Abstract: Thirteen new sphingosine-1-phosphate receptor 1 (S1PR1) ligands were designed and synthesized by replacing azetidine-3-carboxylic acid moiety of compound 4 with new polar groups. The in vitro binding potency of these new analogs toward S1PR1 was determined.… read more here.
Keywords: lead radiotracer; 18f 12b; evaluation; s1pr1 ... See more keywords
Structural insights into sphingosine-1-phosphate receptor activation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117716119
Abstract: As a critical sphingolipid metabolite, sphingosine-1-phosphate (S1P) plays an essential role in immune and vascular systems. There are five S1P receptors, designated as S1PR1-5, encoded in the human genome, and their activities are governed by… read more here.
Keywords: lipid like; s1pr1; receptor activation; activation ... See more keywords
Collecting duct-specific knockout of sphingosine-1-phosphate receptor 1 aggravates DOCA-salt hypertension in mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000002809
Abstract: Objective: We have previously reported that renal medullary sphingosine-1-phosphate (S1P) regulates sodium excretion via the S1P type-1 receptor (S1PR1). As S1PR1 is predominantly expressed in collecting ducts (CD), the present study tested the hypothesis that… read more here.
Keywords: mice; doca salt; sodium; salt ... See more keywords
Endothelial S1pr1 regulates pressure overload‐induced cardiac remodelling through AKT‐eNOS pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14900
Abstract: Cardiac vascular microenvironment is crucial for cardiac remodelling during the process of heart failure. Sphingosine 1‐phosphate (S1P) tightly regulates vascular homeostasis via its receptor, S1pr1. We therefore hypothesize that endothelial S1pr1 might be involved in… read more here.
Keywords: cardiac remodelling; enos pathway; heart failure; s1pr1 ... See more keywords
Programming to S1PR1+ Endothelial Cells Promotes Restoration of Vascular Integrity
Sign Up to like & getrecommendations! Published in 2021 at "Circulation Research"
DOI: 10.1161/circresaha.120.318412
Abstract: Supplemental Digital Content is available in the text. Rationale: Increased endothelial permeability and defective repair are the hallmarks of several vascular diseases, including acute lung injury. However, little is known about the intrinsic pathways activating… read more here.
Keywords: programming s1pr1; generation; s1p; integrity ... See more keywords
MiR-363-3p/S1PR1 axis inhibits sepsis-induced acute lung injury via the inactivation of NF-κB signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental animals"
DOI: 10.1538/expanim.21-0160
Abstract: Infection-associated inflammation and coagulation are critical pathologies in sepsis-induced acute lung injury (ALI). This study aimed to investigate the effects of microRNA-363-3p (miR-363-3p) on sepsis-induced ALI and explore the underlying mechanisms. A cecal ligation and… read more here.
Keywords: acute lung; mir 363; s1pr1; induced acute ... See more keywords
Dialogue between VE-Cadherin and Sphingosine 1 Phosphate Receptor1 (S1PR1) for Protecting Endothelial Functions
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044018
Abstract: The endothelial cells (EC) of established blood vessels in adults remain extraordinarily quiescent in the sense that they are not actively proliferating, but they fulfill the necessary role to control the permeability of their monolayer… read more here.
Keywords: dialogue cadherin; s1pr1; sphingosine; adherens junctions ... See more keywords
Potential biomarkers Ang II/AT1R and S1P/S1PR1 predict the prognosis of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Oncology Letters"
DOI: 10.3892/ol.2020.12071
Abstract: Hepatocellular carcinoma (HCC) is one of the major causes of cancer-associated morbidity and mortality worldwide. Sphingosine-1-phosphate (S1P) and S1P receptor 1 (S1PR1) have been associated with the development and progression of HCC. Angiotensin II (Ang… read more here.
Keywords: hcc; ang at1r; at1r s1p; s1pr1 ... See more keywords
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.52690
Abstract: Despite the medical importance of G protein-coupled receptors (GPCRs), in vivo cellular heterogeneity of GPCR signaling and downstream transcriptional responses are not understood. We report the comprehensive characterization of transcriptomes (bulk and single-cell) and chromatin… read more here.
Keywords: transcriptomes heterogenous; regulated transcriptomes; sphingosine phosphate; s1pr1 ... See more keywords