Exercise activates the hypothalamic S1PR1–STAT3 axis through the central action of interleukin 6 in mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26818
Abstract: Hypothalamic sphingosine‐1‐phosphate receptor 1 (S1PR1), the G protein–coupled receptor 1 of sphingosine‐1‐phosphate, has been described as a modulator in the control of energy homeostasis in rodents. However, this mechanism is still unclear. Here, we evaluate… read more here.
Keywords: stat3 axis; mice; s1pr1; exercise ... See more keywords
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage
Sign Up to like & getrecommendations! Published in 2025 at "Angiogenesis"
DOI: 10.1007/s10456-025-09975-7
Abstract: Neovascular age-related macular degeneration (nAMD) is a major cause of vision loss worldwide. Current standard of care is repetitive intraocular injections of vascular endothelial growth factor (VEGF) inhibitors, although responses may be partial and non-durable.… read more here.
Keywords: s1pr1; s1pr1 suppress; endothelial s1pr1; suppress choroidal ... See more keywords
Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.035
Abstract: Thirteen new sphingosine-1-phosphate receptor 1 (S1PR1) ligands were designed and synthesized by replacing azetidine-3-carboxylic acid moiety of compound 4 with new polar groups. The in vitro binding potency of these new analogs toward S1PR1 was determined.… read more here.
Keywords: lead radiotracer; 18f 12b; evaluation; s1pr1 ... See more keywords
Pseudoirreversible inhibition elicits persistent efficacy of a sphingosine 1-phosphate receptor 1 antagonist
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49893-8
Abstract: Sphingosine 1-phosphate receptor 1 (S1PR1), a G protein-coupled receptor, is required for lymphocyte trafficking, and is a promising therapeutic target in inflammatory diseases. Here, we synthesize a competitive S1PR1 antagonist, KSI-6666, that effectively suppresses pathogenic… read more here.
Keywords: receptor; s1pr1; pseudoirreversible inhibition; sphingosine phosphate ... See more keywords
Thymosin β4 stabilizes hypoxia induced brain microvascular endothelial cell dysfunction through S1PR1 dependent mechanisms.
Sign Up to like & getrecommendations! Published in 2025 at "Scientific reports"
DOI: 10.1038/s41598-025-28435-2
Abstract: Acute ischemic injury causes impairment of blood brain barrier (BBB) permeability and is considered as secondary insult in the brain after traumatic brain injury (TBI). The mechanisms underlying these events are incomprehensible and therefore therapeutic… read more here.
Keywords: endothelial cell; s1pr1; brain; hypoxia induced ... See more keywords
Structural insights into sphingosine-1-phosphate receptor activation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117716119
Abstract: As a critical sphingolipid metabolite, sphingosine-1-phosphate (S1P) plays an essential role in immune and vascular systems. There are five S1P receptors, designated as S1PR1-5, encoded in the human genome, and their activities are governed by… read more here.
Keywords: lipid like; s1pr1; receptor activation; activation ... See more keywords
Zonation, ligand and dose dependence of S1PR1 signalling in blood and lymphatic vasculature.
Sign Up to like & getrecommendations! Published in 2024 at "Cardiovascular research"
DOI: 10.1093/cvr/cvae168
Abstract: AIMS Circulating levels of sphingosine 1-phosphate (S1P), an HDL-associated ligand for endothelial cell (EC) protective S1P receptor-1 (S1PR1), are reduced in disease states associated with endothelial dysfunction. Yet as S1PR1 has high affinity for S1P… read more here.
Keywords: s1pr1; zonation; ligand; s1p ... See more keywords
Collecting duct-specific knockout of sphingosine-1-phosphate receptor 1 aggravates DOCA-salt hypertension in mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000002809
Abstract: Objective: We have previously reported that renal medullary sphingosine-1-phosphate (S1P) regulates sodium excretion via the S1P type-1 receptor (S1PR1). As S1PR1 is predominantly expressed in collecting ducts (CD), the present study tested the hypothesis that… read more here.
Keywords: mice; doca salt; sodium; salt ... See more keywords
Contribution of S1pr1-featured astrocyte subpopulation to cisplatin-induced neuropathic pain in male mice.
Sign Up to like & getrecommendations! Published in 2025 at "Pain"
DOI: 10.1097/j.pain.0000000000003780
Abstract: ABSTRACT Chemotherapy-induced peripheral neuropathy accompanied by neuropathic pain (CIPN) is a major neurotoxicity of cisplatin, a platinum-based drug widely used for lung, ovarian, and testicular cancer treatment. Chemotherapy-induced peripheral neuropathy accompanied by neuropathic pain causes… read more here.
Keywords: s1pr1; pain; neuropathic pain; wnt signaling ... See more keywords
Endothelial S1pr1 regulates pressure overload‐induced cardiac remodelling through AKT‐eNOS pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14900
Abstract: Cardiac vascular microenvironment is crucial for cardiac remodelling during the process of heart failure. Sphingosine 1‐phosphate (S1P) tightly regulates vascular homeostasis via its receptor, S1pr1. We therefore hypothesize that endothelial S1pr1 might be involved in… read more here.
Keywords: cardiac remodelling; enos pathway; heart failure; s1pr1 ... See more keywords
Programming to S1PR1+ Endothelial Cells Promotes Restoration of Vascular Integrity
Sign Up to like & getrecommendations! Published in 2021 at "Circulation Research"
DOI: 10.1161/circresaha.120.318412
Abstract: Supplemental Digital Content is available in the text. Rationale: Increased endothelial permeability and defective repair are the hallmarks of several vascular diseases, including acute lung injury. However, little is known about the intrinsic pathways activating… read more here.
Keywords: programming s1pr1; generation; s1p; integrity ... See more keywords