RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary neural repair through enhancing vascular autophagy in the thalamus after cerebral cortical infarction
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2047344
Abstract: ABSTRACT Cerebral infarction induces angiogenesis in the thalamus and influences functional recovery. The mechanisms underlying angiogenesis remain unclear. This study aimed to investigate the role of RTN4/Nogo-A in mediating macroautophagy/autophagy and angiogenesis in the thalamus… read more here.
Keywords: vascular autophagy; rtn4; thalamus; angiogenesis ... See more keywords
Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11–dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome
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DOI: 10.1097/aln.0000000000002196
Abstract: What We Already Know about This TopicNo molecular-targeted treatments for sepsis have proved successful in humans. The role of sphingosine-1-phosphate receptor 2 (S1PR2) signaling in sepsis is uncertain. What This Article Tells Us That Is… read more here.
Keywords: sepsis; caspase; pyroptosis; macrophage pyroptosis ... See more keywords
Structure of S1PR2–heterotrimeric G13 signaling complex
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DOI: 10.1126/sciadv.abn0067
Abstract: Sphingosine-1-phosphate (S1P) regulates immune cell trafficking, angiogenesis, and vascular function via its five receptors. Inherited mutations in S1P receptor 2 (S1PR2) occur in individuals with hearing loss, and acquired mutations in S1PR2 and Gα13 occur… read more here.
Keywords: heterotrimeric g13; structure; structure s1pr2; s1pr2 heterotrimeric ... See more keywords
Down-regulation of S1PR2 is correlated with poor prognosis and immune infiltrates in cervical squamous cell carcinoma and endocervical adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/03946320231178131
Abstract: Objectives: Cervical squamous cell carcinoma and cervical adenocarcinoma (CESC) are the second leading cause of deaths from malignant tumors in women, while their therapeutic and diagnostic aims are still finited. A growing body of evidence… read more here.
Keywords: cell carcinoma; cesc; prognosis; squamous cell ... See more keywords
The tumor suppressive TGF-β/SMAD1/S1PR2 signaling axis is recurrently inactivated in diffuse large B-cell lymphoma.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2017-10-810630
Abstract: The sphingosine-1-phosphate receptor S1PR2 and its downstream signaling pathway are commonly silenced in diffuse large B-cell lymphoma (DLBCL), either by mutational inactivation or through negative regulation by the oncogenic transcription factor FOXP1. In this study,… read more here.
Keywords: dlbcl; tgf; s1pr2; cell ... See more keywords
Expression of sphingosine-1-phosphate receptor 2 is correlated with migration and invasion of human colon cancer cells: A preliminary clinical study
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DOI: 10.3892/ol.2022.13361
Abstract: Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that serves as a potent mediator of cell proliferation, differentiation and apoptosis by binding to S1P receptors (S1PRs). S1P signalling is involved in the pathogenesis of numerous types of… read more here.
Keywords: migration invasion; expression; migration; cancer ... See more keywords
Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway
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DOI: 10.7150/thno.71585
Abstract: Aims: It is important to understand the mechanism that regulates post-ischemic angiogenesis and to explore a new therapeutic target for an effective improvement of revascularization in peripheral artery disease (PAD) patients. Post-ischemic angiogenesis is a… read more here.
Keywords: blood; post ischemic; ischemic angiogenesis; s1pr2 ... See more keywords