The S1PR2‐CCL2‐BDNF‐TrkB pathway mediates neuroinflammation and motor incoordination in hyperammonaemia
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DOI: 10.1111/nan.12799
Abstract: Chronic hyperammonaemia and inflammation synergistically induce neurological impairment, including motor incoordination, in hepatic encephalopathy. Hyperammonaemic rats show neuroinflammation in the cerebellum which enhances GABAergic neurotransmission leading to motor incoordination. We aimed to identify underlying mechanisms.… read more here.
Keywords: hyperammonaemia; hyperammonaemic rats; s1pr2 ccl2; motor ... See more keywords