Molecular simulation of the Kv7.4[ΔS269] mutant channel reveals that ion conduction in the cavity is perturbed due to hydrophobic gating
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DOI: 10.1016/j.bbrep.2020.100879
Abstract: Mutations in the voltage-gated potassium channel Kv7.4 (encoded as KCNQ4) lead to the early onset of non-syndromic hearing loss, which is significant during language acquisition. The deletion of the S269 pore residue (genetic Δ mutation)… read more here.
Keywords: ion conduction; s269; cavity; kv7 ... See more keywords