S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.
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DOI: 10.2210/pdb6gl8/pdb
Abstract: Escape from apoptosis is one of the major hallmarks of cancer cells. The B-cell Lymphoma 2 (BCL-2) gene family encodes pro-apoptotic and anti-apoptotic proteins that are key regulators of the apoptotic process. Overexpression of the… read more here.
Keywords: selective potent; potent inhibitor; s55746; novel orally ... See more keywords