Trastuzumab stimulation of ribosomal protein S6 kinase 1 (S6K1) predicts de novo trastuzumab resistance.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.072
Abstract: Breast cancer is a complex disease with at least five different molecular subtypes identified. The breast tumor molecular subtypes guide stratification of patients for specific targeted therapy regimens and each subtype is associated with significantly… read more here.
Keywords: trastuzumab resistance; trastuzumab; s6k1; resistance ... See more keywords
S6K1 inhibits HBV replication through inhibiting AMPK-ULK1 pathway and disrupting acetylation modification of H3K27.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118848
Abstract: AIMS To investigated the effect of S6K1 on the replication and transcription of HBV DNA using multiple cell models. MAIN METHODS The pgRNA, total HBV RNA and HBV DNA level were detected by Real-time PCR.… read more here.
Keywords: ampk ulk1; hbv; s6k1; replication inhibiting ... See more keywords
Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52391-3
Abstract: Huntington’s disease (HD) is a fatal inherited autosomal dominant neurodegenerative disorder caused by an expansion in the number of CAG trinucleotide repeats in the huntingtin gene. The disease is characterized by motor, behavioural and cognitive… read more here.
Keywords: huntington disease; disease; s6k1; s6k1 knockout ... See more keywords
A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.150461
Abstract: The ribosomal protein S6 kinase 1 (S6K1) is a relevant effector downstream of the mammalian target of rapamycin complex 1 (mTORC1), best known for its role in the control of lipid homeostasis. Consistent with this,… read more here.
Keywords: mass expansion; fat mass; s6k1; hampers fat ... See more keywords
S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Theranostics"
DOI: 10.7150/thno.22552
Abstract: Rationale: Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc. However, the clinical significances and underlying mechanisms by which Mxi1 is regulated in lung cancer remain poorly… read more here.
Keywords: mxi1; ubiquitin ligase; s6k1; lung cancer ... See more keywords