Isothiocyanates induce autophagy and inhibit protein synthesis in primary cells via modulation of AMPK-mTORC1-S6K1 signaling pathway, and protect against mutant huntingtin aggregation
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Nutrition"
DOI: 10.1007/s00394-024-03539-z
Abstract: Autophagy is a degradation process whose activation underlies beneficial effects of caloric restriction. Isothiocyanates (ITCs) induce autophagy in cancer cells, however, their impact on primary cells remains insufficiently explored, particularly in non-epithelial cells. The aim… read more here.
Keywords: s6k1; ampk; mtorc1; induce autophagy ... See more keywords
Trastuzumab stimulation of ribosomal protein S6 kinase 1 (S6K1) predicts de novo trastuzumab resistance.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.072
Abstract: Breast cancer is a complex disease with at least five different molecular subtypes identified. The breast tumor molecular subtypes guide stratification of patients for specific targeted therapy regimens and each subtype is associated with significantly… read more here.
Keywords: trastuzumab resistance; trastuzumab; s6k1; resistance ... See more keywords
S6K1 inhibits HBV replication through inhibiting AMPK-ULK1 pathway and disrupting acetylation modification of H3K27.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118848
Abstract: AIMS To investigated the effect of S6K1 on the replication and transcription of HBV DNA using multiple cell models. MAIN METHODS The pgRNA, total HBV RNA and HBV DNA level were detected by Real-time PCR.… read more here.
Keywords: ampk ulk1; hbv; s6k1; replication inhibiting ... See more keywords
DEPTOR regulates nucleus pulposus cell senescence through the mTORC1/S6K1/ATG1 pathway to alleviate intervertebral disk degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02819-9
Abstract: This study aimed to determine the molecular mechanisms by which the DEP domain-containing mTOR-interacting protein (DEPTOR) regulates the senescence of nucleus pulposus (NP) cells (NPCs), alleviating intervertebral disk degeneration (IDD). This study investigated how DEPTOR… read more here.
Keywords: s6k1; intervertebral disk; mtorc1; deptor regulates ... See more keywords
Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52391-3
Abstract: Huntington’s disease (HD) is a fatal inherited autosomal dominant neurodegenerative disorder caused by an expansion in the number of CAG trinucleotide repeats in the huntingtin gene. The disease is characterized by motor, behavioural and cognitive… read more here.
Keywords: huntington disease; disease; s6k1; s6k1 knockout ... See more keywords
A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.150461
Abstract: The ribosomal protein S6 kinase 1 (S6K1) is a relevant effector downstream of the mammalian target of rapamycin complex 1 (mTORC1), best known for its role in the control of lipid homeostasis. Consistent with this,… read more here.
Keywords: mass expansion; fat mass; s6k1; hampers fat ... See more keywords
Research on Function of Ribosomal Protein S6 Kinases, 1α and β, Based on Molecular Cloning and siRNA-Based Interference in Juvenile Blunt Snout Bream (Megalobrama amblycephala)
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DOI: 10.3390/biology13110875
Abstract: Simple Summary The aim of this study was to investigate the effects of S6K1α and β on the expression of glycolysis- and gluconeogenesis-related genes in juvenile blunt snout bream. The two isoforms, α and β,… read more here.
Keywords: expression; s6k1; snout bream; blunt snout ... See more keywords
The Role of S6K1 in Aging and Alzheimer’s Disease: Mechanistic Insights and Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26135923
Abstract: Aging is the greatest risk factor for Alzheimer’s disease (AD), but the mechanisms connecting the two remain unclear. The mammalian target of rapamycin (mTOR) pathway, particularly its downstream effector S6 kinase 1 (S6K1), has emerged… read more here.
Keywords: s6k1; alzheimer disease; role s6k1; s6k1 aging ... See more keywords
S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer
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DOI: 10.7150/thno.22552
Abstract: Rationale: Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc. However, the clinical significances and underlying mechanisms by which Mxi1 is regulated in lung cancer remain poorly… read more here.
Keywords: mxi1; ubiquitin ligase; s6k1; lung cancer ... See more keywords