SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112856
Abstract: Renal interstitial fibrosis (RIF) is the common irreversible pathway by which chronic kidney disease (CKD) progresses to the end stage. The transforming growth factor-β (TGF-β)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is… read more here.
Keywords: interstitial fibrosis; saa1; endoplasmic reticulum; reticulum stress ... See more keywords
Regulation of Atherosclerosis by Toll-Like Receptor 4 Induced by Serum Amyloid 1: A Systematic In Vitro Study
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DOI: 10.1155/2022/4887593
Abstract: The objective of this study was to investigate the effects of serum amyloid 1 (SAA1) on activation of endothelial cells, formation of foam cells, platelet aggregation, and monocyte/platelet adhesion to endothelial cells. The effect of… read more here.
Keywords: endothelial cells; platelet adhesion; monocyte platelet; platelet ... See more keywords
Cellular mechanism of fibril formation from serum amyloid A1 protein
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DOI: 10.15252/embr.201643411
Abstract: Serum amyloid A1 (SAA1) is an apolipoprotein that binds to the high‐density lipoprotein (HDL) fraction of the serum and constitutes the fibril precursor protein in systemic AA amyloidosis. We here show that HDL binding blocks… read more here.
Keywords: protein; saa1; formation; fibril formation ... See more keywords
De novo Synthesis of SAA1 in the Placenta Participates in Parturition
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DOI: 10.3389/fimmu.2020.01038
Abstract: Serum amyloid A1 (SAA1) is an acute phase protein produced mainly by the liver to participate in immunomodulation in both sterile and non-sterile inflammation. However, non-hepatic tissues can also synthesize SAA1. It remains to be… read more here.
Keywords: placenta participates; saa1; participates parturition; parturition ... See more keywords
SAA1 Has Potential as a Prognostic Biomarker Correlated with Cell Proliferation, Migration, and an Indicator for Immune Infiltration of Tumor Microenvironment in Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087505
Abstract: The tumor microenvironment (TME) plays an important part in the initiation and development of clear cell renal cell carcinoma (ccRCC). However, an understanding of the immune infiltration in TME is still unknown. Our study aims… read more here.
Keywords: cell; proliferation migration; cell proliferation; expression ... See more keywords