Antimicrobial Peptide SAAP‐148‐Functionalized Hydrogels from Photocrosslinkable Polymers with Broad Antibacterial Activity
Sign Up to like & getrecommendations! Published in 2024 at "Macromolecular Rapid Communications"
DOI: 10.1002/marc.202400785
Abstract: Abstract Antimicrobial peptides (AMPs) are promising alternatives to traditional antibiotics for treating skin wound infections. Nonetheless, their short half‐life in biological environments restricts clinical applicability. Covalent immobilization of AMPs onto suitable substrates offers a comprehensive… read more here.
Keywords: antimicrobial peptide; 148 functionalized; saap 148; peptide saap ... See more keywords
High-Throughput Identification of Antibacterials Against Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.591426
Abstract: Antibiotic resistance is a growing public health concern, though the constant development of new antibiotics. The combination of high-throughput screening and drug repurposing is an effective way to develop new therapeutic uses of drugs. In… read more here.
Keywords: pseudomonas aeruginosa; throughput; saap 148; aeruginosa high ... See more keywords
SAAP-148 Eradicates MRSA Persisters Within Mature Biofilm Models Simulating Prosthetic Joint Infection
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.625952
Abstract: Prosthetic joint infection (PJI) is a severe complication of arthroplasty. Due to biofilm and persister formation current treatment strategies often fail. Therefore, innovative anti-biofilm and anti-persister agents are urgently needed. Antimicrobial peptides with their broad… read more here.
Keywords: mature; biofilm; prosthetic joint; exposed mature ... See more keywords
Synergism between the Synthetic Antibacterial and Antibiofilm Peptide (SAAP)-148 and Halicin
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11050673
Abstract: Recently, using a deep learning approach, the novel antibiotic halicin was discovered. We compared the antibacterial activities of two novel bactericidal antimicrobial agents, i.e., the synthetic antibacterial and antibiofilm peptide (SAAP)-148 with this antibiotic halicin.… read more here.
Keywords: antibiofilm peptide; synthetic antibacterial; halicin; antibacterial antibiofilm ... See more keywords
Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020429
Abstract: Chronic wound infections colonized by bacteria are becoming more difficult to treat with current antibiotics due to the development of antimicrobial resistance (AMR) as well as biofilm and persister cell formation. Synthetic antibacterial and antibiofilm… read more here.
Keywords: skin; wound infections; octenyl succinic; treatment ... See more keywords
The Mechanism of Action of SAAP-148 Antimicrobial Peptide as Studied with NMR and Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15030761
Abstract: Background: SAAP-148 is an antimicrobial peptide derived from LL-37. It exhibits excellent activity against drug-resistant bacteria and biofilms while resisting degradation in physiological conditions. Despite its optimal pharmacological properties, its mechanism of action at the… read more here.
Keywords: dynamics simulations; antimicrobial peptide; molecular dynamics; mechanism action ... See more keywords