Design, synthesis, SAR, and biological evaluation of saccharin‐based hybrids as carbonic anhydrase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200019
Abstract: Saccharin is a cyclic secondary sulfonamide, which is a selective inhibitor of the tumor‐associated carbonic anhydrase (CA; EC 4.2.1.1) enzymes CA IX and CA XII compared to many primary sulfonamides. In this study, new saccharin‐1,2,3‐triazole… read more here.
Keywords: design synthesis; carbonic anhydrase; hca; hca hca ... See more keywords
Sucrose and saccharin differentially modulate depression and anxiety-like behavior in diabetic mice: exposures and withdrawal effects
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05259-3
Abstract: RationaleSugar has addictive potential owing to increase in monoaminergic-transmission at pleasure and reward centers of brain. Insulin dysfunction triggered synaptic monoamine deficit is associated with sugar overeating and craving-related psychological changes in diabetic patients. Sugar-substitute… read more here.
Keywords: saccharin; water; mice; diabetic mice ... See more keywords
Adolescent and adult nicotine exposure differentially impacts oral nicotine and oral saccharin self-administration in mice
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.07.019
Abstract: HighlightsAdolescent nicotine exposure increased saccharin reinforcement in adulthood.Adult nicotine re‐exposure biased the sensitivity towards nicotine reward.Both adolescent and adult nicotine exposure increased impulsive responding.Adolescent and adult nicotine experience activated distinct behavioral mechanisms.These mechanisms acted in… read more here.
Keywords: oral nicotine; saccharin; nicotine exposure; exposure ... See more keywords
High-throughput quantification of sodium saccharin in foods by ambient flame ionization mass spectrometry.
Sign Up to like & getrecommendations! Published in 2018 at "Talanta"
DOI: 10.1016/j.talanta.2018.01.071
Abstract: Ambient flame ionization (AFI) coupled with triple quadrupole tandem mass spectrometry was developed for quantitative analysis of sodium saccharin (SAC) in various food samples. Typically, the micro-flame by the combustion of n-butane provided a heating… read more here.
Keywords: flame ionization; saccharin; mass spectrometry; quantification ... See more keywords
A Convenient Synthetic Approach to Saccharin Derivatives Containing a Sulfonylamidine Scaffold
Sign Up to like & getrecommendations! Published in 2018 at "Synthesis"
DOI: 10.1055/s-0036-1591882
Abstract: A key intermediate was obtained as solid through filtration of the reaction mixture of saccharin, chloro(triphenyl)phosphonium chloride, and N,N-diisopropylethylamine (DIPEA) in chloroform. The soluble triphenylphosphine oxide went to filtrate as waste, while the solid was… read more here.
Keywords: saccharin; sulfonylamidine; saccharin derivatives; convenient synthetic ... See more keywords
Synthesis and characterization of meloxicam eutectics with mandelic acid and saccharin for enhanced solubility
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2020.1775633
Abstract: Abstract Meloxicam (MLX) is a non-steroidal anti-inflammatory which is practically insoluble in water, requiring high concentrations to reach therapeutic levels and causing frequently gastrointestinal effects. In this way, the aim of this study was to… read more here.
Keywords: mlx; saccharin; enhanced solubility; mandelic acid ... See more keywords
Distracting stimuli evoke ventral tegmental area responses in rats during ongoing saccharin consumption
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15108
Abstract: Disruptions in attention, salience and increased distractibility are implicated in multiple psychiatric conditions. The ventral tegmental area (VTA) is a potential site for converging information about external stimuli and internal states to be integrated and… read more here.
Keywords: saccharin; tegmental area; distracting stimuli; ventral tegmental ... See more keywords
Saccharin-assisted Galvanostatic Electrodeposition of Nanocrystalline FeCo Films on a Flexible Substrate
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Electrochemical Science"
DOI: 10.20964/2020.07.74
Abstract: The electrodeposition of functional materials on a flexible substrate has become an interesting topic because of the current development of flexible devices, called flexible technology, for various electronic applications. This study investigated FeCo film electrodeposition… read more here.
Keywords: saccharin; deposition temperature; electrodeposition; flexible substrate ... See more keywords
Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Structural Biology"
DOI: 10.2210/pdb6gcy/pdb
Abstract: Up-regulation of carbonic anhydrase IX (CA IX) expression is an indicator of metastasis and associated with poor cancer patient prognosis. CA IX has emerged as a cancer drug target but development of isoform-specific inhibitors is… read more here.
Keywords: saccharin; crystallography; basis; carbonic anhydrase ... See more keywords
Saccharin Stimulates Insulin Secretion Dependent on Sweet Taste Receptor-Induced Activation of PLC Signaling Axis
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10010120
Abstract: Background: Saccharin is a common artificial sweetener and a bona fide ligand for sweet taste receptors (STR). STR can regulate insulin secretion in beta cells, so we investigated whether saccharin can stimulate insulin secretion dependent… read more here.
Keywords: secretion dependent; secretion; plc signaling; saccharin ... See more keywords
Effect of β-oxidation stimulant against metabolic syndrome of saccharin in rat: A behavioral, biochemical, and histological study
Sign Up to like & getrecommendations! Published in 2020 at "journal of applied pharmaceutical science"
DOI: 10.7324/japs.2021.110106
Abstract: Introduction: Saccharin (Sac) is a sweetener that is still regarded as a carcinogen and diabetic inducer in some parts of the world. In the current study, we explored the effects of coenzyme Q10 (COQ10) against… read more here.
Keywords: metabolic syndrome; group sac; saccharin; treatment group ... See more keywords