Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.
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DOI: 10.1016/j.ejmech.2016.09.078
Abstract: The complexity of Alzheimer's disease (AD) calls for search of multifunctional compounds as potential candidates for effective therapy. A series of phthalimide and saccharin derivatives linked by different alicyclic fragments (piperazine, hexahydropyrimidine, 3-aminopyrrolidine or 3-aminopiperidine)… read more here.
Keywords: secretase amyloid; saccharin derivatives; phthalimide saccharin; beta ... See more keywords
A Convenient Synthetic Approach to Saccharin Derivatives ÂContaining a Sulfonylamidine Scaffold
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DOI: 10.1055/s-0036-1591882
Abstract: A key intermediate was obtained as solid through filtration of the reaction mixture of saccharin, chloro(triphenyl)phosphonium chloride, and N,N-diisopropylethylamine (DIPEA) in chloroform. The soluble triphenylphosphine oxide went to filtrate as waste, while the solid was… read more here.
Keywords: saccharin; sulfonylamidine; saccharin derivatives; convenient synthetic ... See more keywords
Catalytic Applications of Saccharin and its Derivatives in Organic Synthesis
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DOI: 10.2174/1385272823666191121144758
Abstract: Saccharin (1,2-benzisothiazol-3(2H)-one-1,1-dioxide) is a very mild, cheap, commercially available, water soluble, environmentally benign and edible Brønsted acidic substance. Recently, with other utilities, saccharin and its derivatives were employed as catalysts for various organic transformations. In… read more here.
Keywords: applications saccharin; organic synthesis; saccharin derivatives; chemistry ... See more keywords