Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS‐CoV‐2 infection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12179
Abstract: Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) entry is mediated by the interaction of the viral spike (S) protein with angiotensin‐converting enzyme 2 (ACE2) on the host cell surface. Although a clinical trial testing… read more here.
Keywords: sars cov; extracellular vesicles; infection; small extracellular ... See more keywords
Comparative docking studies to understand the binding affinity of nicotine with soluble ACE2 (sACE2)-SARS-CoV-2 complex over sACE2
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology Reports"
DOI: 10.1016/j.toxrep.2020.10.002
Abstract: The study aimed to validate the proficiency of nicotine binding with the soluble angiotensin-converting enzyme II receptor (sACE2) with or without SARS-CoV-2 in the context of its binding affinity. Modelled human sACE2 and the spike… read more here.
Keywords: nicotine; sace2; complex sace2; sars cov ... See more keywords
In vivo HSC gene therapy for SARS-CoV2 infection using a decoy receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Human gene therapy"
DOI: 10.1089/hum.2021.295
Abstract: While SARS-CoV2 vaccines have shown an unprecedented success, the ongoing emergence of new variants and necessity to adjust vaccines justifies the development of alternative prophylaxis and therapy approaches. Hematopoietic stem cell (HSC) gene therapy using… read more here.
Keywords: sars cov2; vivo; vivo hsc; therapy ... See more keywords
Profiling Levels of Serum microRNAs and Soluble ACE2 in COVID-19 Patients
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12040575
Abstract: Background: The main mechanism of viral entry in COVID-19 infection is through the angiotensin-converting enzyme 2 (ACE2) receptor present in the lungs. Numerous studies suggested a clinical significance of risk factors, such as gender, obesity,… read more here.
Keywords: sace2; covid patients; mir 212; covid ... See more keywords