Development and validation of a novel stability-indicating reverse phase HPLC method for the determination of sacubitril-valsartan premix stereoisomers: Cellulose tris(4-methyl benzoate) stationary phase.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200363
Abstract: A new stability indicating reverse phase HPLC method has been developed, optimized and validated as per International Conference on Harmonization guidelines for the determination of stereoisomers namely (2R)-valsartan, (2S,4S)-sacubitril, (2R,4S)-sacubitril and (2R,4R)-sacubitril in sacubitril-valsartan premix.… read more here.
Keywords: sacubitril valsartan; stability indicating; reverse phase; sacubitril ... See more keywords
Interaction Between Sacubitril and Valsartan in Preventing Heart Failure Induced by Aortic Valve Insufficiency in Rats.
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DOI: 10.1016/j.cardfail.2019.09.008
Abstract: BACKGROUND Synergistic interactions between neprilysin inhibition (NEPi) with sacubitril and angiotensin receptor type1 blockade (ARB) with valsartan have been implicated in improvement of left ventricular (LV) contractility, relaxation, exercise tolerance, and fibrosis in preexisting heart… read more here.
Keywords: sacubitril; failure; aortic valve; sacubitril valsartan ... See more keywords
WORSENING RENAL FUNCTION, HYPERKALEMIA AND HYPOTENSION IN SACUBITRIL-VALSARTAN VS. ENALAPRIL IN HFREF: A META-ANALYSIS
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(20)31595-3
Abstract: Sacubitril-valsartan has shown significant promise in patients with Heart Failure with reduced Ejection Fraction (HFrEF). We compared the safety of the sacubitril-valsartan with enalapril in patients with HFrEF. A comprehensive search was performed on PubMed,… read more here.
Keywords: sacubitril; sacubitril valsartan; valsartan enalapril; worsening renal ... See more keywords
Beneficial electrophysiologic effects of sacubitril in different arrhythmia syndromes
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DOI: 10.1093/ehjci/ehaa946.0327
Abstract: Previous studies report conflicting data regarding anti- or proarrhythmic effects of sacubitril. The aim of the presents study was to assess the impact of sacubitril in different arrhythmia models. In 12 isolated rabbit hearts, sacubitril… read more here.
Keywords: sacubitril; effects sacubitril; different arrhythmia; sacubitril different ... See more keywords
Sacubitril/Valsartan for heart failure
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DOI: 10.1097/md.0000000000029149
Abstract: Abstract Background: Sacubitril–valsartan has been shown to have superior effects over angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with heart failure (HF). However, the effects of sacubitril–valsartan have never been systematically evaluated. Therefore,… read more here.
Keywords: sacubitril; heart failure; sacubitril valsartan; valsartan heart ... See more keywords
Sacubitril/valsartan can improve the cardiac function in heart failure patients with a history of cancer: An observational study
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DOI: 10.1097/md.0000000000037613
Abstract: Sacubitril/Valsartan, the combination of angiotensin receptor inhibitor and neprilysin inhibitor, is now becoming the class 1 recommendation for HFrEF. Some studies have shown the positive effect of Sacubitril/Valsartan on HFrEF cancer patients, while there is… read more here.
Keywords: cancer; history; group; sacubitril ... See more keywords
Novel Isocratic HPLC Method for Simultaneous Estimation of Sacubitril and Valsartan in Bulk and Formulation
Sign Up to like & getrecommendations! Published in 2025 at "Brazilian Archives of Biology and Technology"
DOI: 10.1590/1678-4324-2025240353
Abstract: Abstract In compliance with ICH requirements, a new selective, precise, and accurate reverse-phase High-Performance Liquid Chromatographic method for valsartan and sacubitril quantification was developed and validated. Eluents were detected at 284 nm. The HPLC method… read more here.
Keywords: valsartan sacubitril; hplc method; sacubitril;
Efficacy and safety of sacubitril/valsartan on heart failure with preserved ejection fraction: A meta-analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.897423
Abstract: Aims The efficacy and safety of sacubitril/valsartan for patients with heart failure with preserved ejection fraction (HFpEF) are controversial. Hence, the primary objective of the study was to evaluate the efficacy and safety of sacubitril/valsartan… read more here.
Keywords: heart failure; sacubitril valsartan; sacubitril; efficacy safety ... See more keywords
Transfer RNA-derived small RNAs and their potential roles in the therapeutic heterogeneity of sacubitril/valsartan in heart failure patients after acute myocardial infarction
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DOI: 10.3389/fcvm.2022.961700
Abstract: Background It has been reported that sacubitril/valsartan can improve cardiac function in acute myocardial infarction (AMI) patients complicated by heart failure (HF). However, a number of patients cannot be treated successfully; this phenomenon is called… read more here.
Keywords: sacubitril valsartan; therapeutic heterogeneity; myocardial infarction; sacubitril ... See more keywords
Divergent Electrophysiologic Effects of Sacubitril in Digitalis- and Pinacidil-Related Shortened Repolarization: Experimental Evidence for Harmful Effects of Digitalis Glycosides
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DOI: 10.3390/pharmaceutics17030338
Abstract: Background: Recent studies reported an abbreviation of cardiac repolarization induced by sacubitril. Thus, the purpose of this study was to evaluate the electrophysiologic effects of sacubitril in the presence of drugs that shorten the QT… read more here.
Keywords: repolarization; shortened repolarization; electrophysiologic effects; sacubitril ... See more keywords
Initial clinical experience with the first drug (sacubitril/valsartan) in a new class - angiotensin receptor neprilysin inhibitors in patients with heart failure with reduced left ventricular ejection fraction in Poland.
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DOI: 10.5603/kp.a2017.0230
Abstract: BACKGROUND Sacubitril/valsartan is the first drug from a new class of angiotensin receptor neprilysin inhibitors (ARNIs) recommended in the new European Society of Cardiology guidelines instead of angiotensin converting enzyme inhibitors (ACEI), or angiotensin receptor… read more here.
Keywords: sacubitril; sacubitril valsartan; cardiology; class ... See more keywords