Development and validation of a novel stability-indicating reverse phase HPLC method for the determination of sacubitril-valsartan premix stereoisomers: Cellulose tris(4-methyl benzoate) stationary phase.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200363
Abstract: A new stability indicating reverse phase HPLC method has been developed, optimized and validated as per International Conference on Harmonization guidelines for the determination of stereoisomers namely (2R)-valsartan, (2S,4S)-sacubitril, (2R,4S)-sacubitril and (2R,4R)-sacubitril in sacubitril-valsartan premix.… read more here.
Keywords: sacubitril valsartan; stability indicating; reverse phase; sacubitril ... See more keywords
Interaction Between Sacubitril and Valsartan in Preventing Heart Failure Induced by Aortic Valve Insufficiency in Rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2019.09.008
Abstract: BACKGROUND Synergistic interactions between neprilysin inhibition (NEPi) with sacubitril and angiotensin receptor type1 blockade (ARB) with valsartan have been implicated in improvement of left ventricular (LV) contractility, relaxation, exercise tolerance, and fibrosis in preexisting heart… read more here.
Keywords: sacubitril; failure; aortic valve; sacubitril valsartan ... See more keywords
WORSENING RENAL FUNCTION, HYPERKALEMIA AND HYPOTENSION IN SACUBITRIL-VALSARTAN VS. ENALAPRIL IN HFREF: A META-ANALYSIS
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(20)31595-3
Abstract: Sacubitril-valsartan has shown significant promise in patients with Heart Failure with reduced Ejection Fraction (HFrEF). We compared the safety of the sacubitril-valsartan with enalapril in patients with HFrEF. A comprehensive search was performed on PubMed,… read more here.
Keywords: sacubitril; sacubitril valsartan; valsartan enalapril; worsening renal ... See more keywords
Beneficial electrophysiologic effects of sacubitril in different arrhythmia syndromes
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.0327
Abstract: Previous studies report conflicting data regarding anti- or proarrhythmic effects of sacubitril. The aim of the presents study was to assess the impact of sacubitril in different arrhythmia models. In 12 isolated rabbit hearts, sacubitril… read more here.
Keywords: sacubitril; effects sacubitril; different arrhythmia; sacubitril different ... See more keywords
Sacubitril/Valsartan for heart failure
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029149
Abstract: Abstract Background: Sacubitril–valsartan has been shown to have superior effects over angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with heart failure (HF). However, the effects of sacubitril–valsartan have never been systematically evaluated. Therefore,… read more here.
Keywords: sacubitril; heart failure; sacubitril valsartan; valsartan heart ... See more keywords
Efficacy and safety of sacubitril/valsartan on heart failure with preserved ejection fraction: A meta-analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.897423
Abstract: Aims The efficacy and safety of sacubitril/valsartan for patients with heart failure with preserved ejection fraction (HFpEF) are controversial. Hence, the primary objective of the study was to evaluate the efficacy and safety of sacubitril/valsartan… read more here.
Keywords: heart failure; sacubitril valsartan; sacubitril; efficacy safety ... See more keywords
Transfer RNA-derived small RNAs and their potential roles in the therapeutic heterogeneity of sacubitril/valsartan in heart failure patients after acute myocardial infarction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.961700
Abstract: Background It has been reported that sacubitril/valsartan can improve cardiac function in acute myocardial infarction (AMI) patients complicated by heart failure (HF). However, a number of patients cannot be treated successfully; this phenomenon is called… read more here.
Keywords: sacubitril valsartan; therapeutic heterogeneity; myocardial infarction; sacubitril ... See more keywords
Initial clinical experience with the first drug (sacubitril/valsartan) in a new class - angiotensin receptor neprilysin inhibitors in patients with heart failure with reduced left ventricular ejection fraction in Poland.
Sign Up to like & getrecommendations! Published in 2018 at "Kardiologia polska"
DOI: 10.5603/kp.a2017.0230
Abstract: BACKGROUND Sacubitril/valsartan is the first drug from a new class of angiotensin receptor neprilysin inhibitors (ARNIs) recommended in the new European Society of Cardiology guidelines instead of angiotensin converting enzyme inhibitors (ACEI), or angiotensin receptor… read more here.
Keywords: sacubitril; sacubitril valsartan; cardiology; class ... See more keywords