Regulatory control of DNA end resection by Sae2 phosphorylation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06417-5
Abstract: DNA end resection plays a critical function in DNA double-strand break repair pathway choice. Resected DNA ends are refractory to end-joining mechanisms and are instead channeled to homology-directed repair. Using biochemical, genetic, and imaging methods,… read more here.
Keywords: sae2; end resection; end; dna end ... See more keywords
Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky086
Abstract: Abstract Sae2 cooperates with the Mre11–Rad50-Xrs2 (MRX) complex to initiate resection of DNA double-strand breaks (DSBs) and to maintain the DSB ends in close proximity to allow their repair. How these diverse MRX-Sae2 functions contribute… read more here.
Keywords: dna damage; sae2; end tethering; resistance ... See more keywords