Rewiring of the FtsH regulatory network by a single nucleotide change in saeS of Staphylococcus aureus
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DOI: 10.1038/s41598-017-08774-5
Abstract: In the Gram-positive pathogen Staphylococcus aureus, the membrane-bound ATP-dependent metalloprotease FtsH plays a critical role in resistance to various stressors. However, the molecular mechanism of the FtsH functions is not known. Here, we identified core… read more here.
Keywords: saes; staphylococcus aureus; regulatory network; ftsh ... See more keywords
Master transcriptional regulator SaeS in Staphylococcus aureus contributes to staphyloxanthin biosynthesis to promote survival during invasive infection
Sign Up to like & getrecommendations! Published in 2025 at "Virulence"
DOI: 10.1080/21505594.2025.2580159
Abstract: ABSTRACT Staphylococcus aureus is a major human opportunistic pathogen that causes significant morbidity and mortality, particularly in immunocompromised individuals. SaeRS is a two-component system in S. aureus that regulates signal transduction related to virulence, including… read more here.
Keywords: system; survival; virulence; saes ... See more keywords
A phase II study evaluating the efficacy and safety of imetelstat in patients with advanced myelodysplastic neoplasms or AML failing HMA-based therapy – interim analysis results of the IMpress study
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DOI: 10.1182/blood-2025-5155
Abstract: Platzbecker U, Lane S and Adès L contributed equally. A study by the European Myelodysplastic Neoplasms Cooperative Group (EMSCO) Introduction: Hypomethylating agents (HMAs), either as monotherapy or combined with venetoclax (VEN), are standard of care… read more here.
Keywords: disease; cohort; saes; mds ... See more keywords
The high incidence of severe adverse events due to pyrazinamide in elderly patients with tuberculosis
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DOI: 10.1371/journal.pone.0236109
Abstract: Background Pyrazinamide (PZA) is a common drug that causes serious adverse events (SAEs). The aim of this study was to determine the incidence of and risk factors for SAEs due to PZA during first-line anti-tuberculosis… read more here.
Keywords: incidence; saes; drug; patients tuberculosis ... See more keywords
Serious Adverse Events Reporting in Phase III Randomized Clinical Trials of Colorectal Cancer Treatments: A Systematic Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.754858
Abstract: Objective: The occurrence, development, and prognosis of serious adverse events (SAEs) associated with anticancer drugs in clinical trials have important guiding significance for real-world clinical applications. However, to date, there have been no studies investigating… read more here.
Keywords: saes; trials colorectal; cancer treatments; clinical trials ... See more keywords