Rewiring of the FtsH regulatory network by a single nucleotide change in saeS of Staphylococcus aureus
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DOI: 10.1038/s41598-017-08774-5
Abstract: In the Gram-positive pathogen Staphylococcus aureus, the membrane-bound ATP-dependent metalloprotease FtsH plays a critical role in resistance to various stressors. However, the molecular mechanism of the FtsH functions is not known. Here, we identified core… read more here.
Keywords: saes; staphylococcus aureus; regulatory network; ftsh ... See more keywords
The high incidence of severe adverse events due to pyrazinamide in elderly patients with tuberculosis
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DOI: 10.1371/journal.pone.0236109
Abstract: Background Pyrazinamide (PZA) is a common drug that causes serious adverse events (SAEs). The aim of this study was to determine the incidence of and risk factors for SAEs due to PZA during first-line anti-tuberculosis… read more here.
Keywords: incidence; saes; drug; patients tuberculosis ... See more keywords
Serious Adverse Events Reporting in Phase III Randomized Clinical Trials of Colorectal Cancer Treatments: A Systematic Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.754858
Abstract: Objective: The occurrence, development, and prognosis of serious adverse events (SAEs) associated with anticancer drugs in clinical trials have important guiding significance for real-world clinical applications. However, to date, there have been no studies investigating… read more here.
Keywords: saes; trials colorectal; cancer treatments; clinical trials ... See more keywords