Blastocyst Formation Rate and Transgene Expression are Associated with Gene Insertion into Safe and Non-Safe Harbors in the Cattle Genome
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DOI: 10.1038/s41598-017-15648-3
Abstract: Integration target site is the most important factor in successful production of transgenic animals. However, stable expression of transgene without disturbing the function of the host genome depends on promoter methylation, transgene copy number and… read more here.
Keywords: non safe; expression; rate; safe non ... See more keywords
Identification of Genomic Safe Harbors in the Anhydrobiotic Cell Line, Pv11
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DOI: 10.3390/genes13030406
Abstract: Genomic safe harbors (GSHs) provide ideal integration sites for generating transgenic organisms and cells and can be of great benefit in advancing the basic and applied biology of a particular species. Here we report the… read more here.
Keywords: cell line; safe harbors; pv11; cell ... See more keywords