Safety and clinical activity of adenosine A2a receptor (A2aR) antagonist, CPI-444, in anti-PD1/PDL1 treatment-refractory renal cell (RCC) and non-small cell lung cancer (NSCLC) patients.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.3004
Abstract: 3004Background: Adenosine production in the tumor leads to immunosuppression through A2aR on infiltrating immune cells. CPI-444 is an oral A2aR antagonist with single agent(SA) anti-tumor activity ... read more here.
Keywords: a2ar antagonist; clinical activity; cell; safety clinical ... See more keywords
Safety and clinical activity of durvalumab monotherapy in patients with hepatocellular carcinoma (HCC).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.4071
Abstract: 4071Background: Durvalumab, an anti-PD-L1 mAb, has shown early and durable clinical activity with manageable safety in an ongoing Phase 1/2, multicenter, open-label study in pts with advanced solid... read more here.
Keywords: durvalumab monotherapy; clinical activity; activity durvalumab; activity ... See more keywords
Safety and clinical activity of durvalumab in combination with tremelimumab in extensive disease small-cell lung cancer (ED-SCLC).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.8517
Abstract: 8517Background: Treatment options for ED-SCLC are limited, with standard first-line platinum and etoposide and second-line topotecan having limited clinical activity. Beyond these agents, no approv... read more here.
Keywords: combination tremelimumab; durvalumab combination; clinical activity; activity durvalumab ... See more keywords
[Quality and safety in clinical nutrition].
Sign Up to like & getrecommendations! Published in 2022 at "Nutricion hospitalaria"
DOI: 10.20960/nh.04067
Abstract: Clinical nutrition and food provision in a hospital environment must be regulated by quality management programs that ensure maximum clinical benefit and maximum patient safety. This article gives an overview of quality management in clinical… read more here.
Keywords: nutrition; safety clinical; clinical nutrition; quality safety ... See more keywords
Safety of Clinical Ultrasound Neuromodulation
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DOI: 10.3390/brainsci12101277
Abstract: Transcranial ultrasound holds much potential as a safe, non-invasive modality for navigated neuromodulation, with low-intensity focused ultrasound (FUS) and transcranial pulse stimulation (TPS) representing the two main modalities. While neuroscientific and preclinical applications have received… read more here.
Keywords: clinical ultrasound; safety clinical; safety; ultrasound neuromodulation ... See more keywords
In Response to Huhn et al RE: Hypothalamic Pituitary Adrenocortical Axis Suppression Following a Single Epidural Injection of Methylprednisolone Acetate: Review, Patient Safety and Clinical Care.
Sign Up to like & getrecommendations! Published in 2018 at "Pain physician"
DOI: 10.36076/ppj.2018.3.e288
Abstract: We appreciate the authors’ interest and their valuable input (1) in our published article (2). We agree that written discharge instructions need to be provided to patients including type and quantity of the steroid, date,… read more here.
Keywords: suppression; injection; axis suppression; following single ... See more keywords