Safety and Efficacy of Deucravacitinib in Moderate to Severe Plaque Psoriasis for Up to 3 Years
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2024.4688
Abstract: Key Points Question What is the safety and efficacy of continuous treatment with deucravacitinib over a 3-year period? Findings In this integrated analysis of the phase 3 POETYK PSO-1, PSO-2, and nonrandomized long-term extension trials… read more here.
Keywords: moderate severe; severe plaque; safety efficacy; safety ... See more keywords
Safety and efficacy of unilateral and bilateral pallidotomy for primary dystonia
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51333
Abstract: Ablation of the globus pallidus internus (pallidotomy) is an effective surgical intervention for dystonia. However, the current literature on the efficacy and safety of pallidotomy for dystonia is derived only from single‐case reports and small… read more here.
Keywords: efficacy unilateral; safety efficacy; dystonia; pallidotomy ... See more keywords
Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE‐TPA): A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Study
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25644
Abstract: Otaplimastat is a neuroprotectant that inhibits matrix metalloprotease pathway, and reduces edema and intracerebral hemorrhage induced by recombinant tissue plasminogen activator (rtPA) in animal stroke models. We aimed to assess the safety and efficacy of… read more here.
Keywords: safety efficacy; efficacy otaplimastat; otaplimastat patients; stroke ... See more keywords
Safety and efficacy of intravenous thrombolytic treatment in wake‐up stroke: Experiences from a single center
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2152
Abstract: Wake‐up stroke is an important clinical problem that may account for a quarter of all ischemic strokes. This study aimed to establish the safety and efficacy of intravenous thrombolytic treatment of wake‐up strokes by comparing… read more here.
Keywords: safety efficacy; efficacy intravenous; treatment; wake ... See more keywords
Impact of IgG Fc‐Oligosaccharides on Recombinant Monoclonal Antibody Structure, Stability, Safety, and Efficacy
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2498
Abstract: Glycosylation of the conserved asparagine residue in the CH2 domain is the most common posttranslational modification of recombinant monoclonal antibodies. Ideally, a consistent oligosaccharide profile should be maintained from early clinical material to commercial material… read more here.
Keywords: impact; safety efficacy; safety; recombinant monoclonal ... See more keywords
Safety and efficacy profile of cyclin‐dependent kinases 4/6 inhibitor palbociclib in cancer therapy: A meta‐analysis of clinical trials
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1970
Abstract: Palbociclib is a small‐molecule, cyclin‐dependent kinase 4 and 6 inhibitor, which prevents phosphorylation of the retinoblastoma (Rb) protein and inhibits cell‐cycle progression from G1 to S phase. We performed this meta‐analysis to estimate the safety… read more here.
Keywords: cyclin dependent; safety efficacy; clinical trials; palbociclib cancer ... See more keywords
Safety and Efficacy of Rechallenge With Immune Checkpoint Inhibitors in Advanced Solid Tumor: A Systematic Review and Meta‐Analysis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70324
Abstract: Immune checkpoint inhibitors (ICIs) have drastically shifted the current landscape toward a wide variety of malignancies. However, ICIs are interrupted owing immune‐related adverse events (irAEs), therapy completion, and disease progression. The risk–benefit of rechallenged ICIs… read more here.
Keywords: meta analysis; immune checkpoint; systematic review; review meta ... See more keywords
Safety and efficacy of ulnar artery approach for percutaneous cardiac catheterization: Systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2018 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.27479
Abstract: Trans‐radial access has rapidly become the standard for percutaneous coronary procedures in the last decade. As proceduralists overcome the learning curve and become more competent in trans‐radial access, alternative safe access sites such as the… read more here.
Keywords: artery; safety efficacy; efficacy ulnar; cardiac catheterization ... See more keywords
Long‐term clinical safety and efficacy of drug‐coated balloon in the treatment of in‐stent restenosis: A meta‐analysis and systematic review
Sign Up to like & getrecommendations! Published in 2019 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.28572
Abstract: The aim of this study was to evaluate the long‐term clinical safety and efficacy of drug‐coated balloon (DCB) in the treatment of in‐stent restenosis (ISR). read more here.
Keywords: term clinical; efficacy drug; long term; safety efficacy ... See more keywords
Safety and efficacy of drug‐coated balloon for peripheral artery revascularization—A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.30074
Abstract: The relative merits of the drug‐coated balloon (DCB) versus uncoated balloon (UCB) angioplasty in endovascular intervention for patients with symptomatic lower extremity peripheral arterial disease (PAD) remains controversial. read more here.
Keywords: balloon; safety efficacy; coated balloon; drug coated ... See more keywords
Safety and efficacy of transcatheter mitral valve repair in patients with COPD; results from real‐world cohort
Sign Up to like & getrecommendations! Published in 2022 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.30238
Abstract: To evaluate the safety and efficacy of transcatheter mitral valve repair (TMVR) in patients with chronic obstructive pulmonary disease (COPD). read more here.
Keywords: efficacy transcatheter; valve repair; safety efficacy; mitral valve ... See more keywords