Articles with "safety efficacy" as a keyword



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Safety and efficacy of unilateral and bilateral pallidotomy for primary dystonia

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Published in 2021 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.51333

Abstract: Ablation of the globus pallidus internus (pallidotomy) is an effective surgical intervention for dystonia. However, the current literature on the efficacy and safety of pallidotomy for dystonia is derived only from single‐case reports and small… read more here.

Keywords: efficacy unilateral; safety efficacy; dystonia; pallidotomy ... See more keywords
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Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE‐TPA): A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Phase 2 Study

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Published in 2019 at "Annals of Neurology"

DOI: 10.1002/ana.25644

Abstract: Otaplimastat is a neuroprotectant that inhibits matrix metalloprotease pathway, and reduces edema and intracerebral hemorrhage induced by recombinant tissue plasminogen activator (rtPA) in animal stroke models. We aimed to assess the safety and efficacy of… read more here.

Keywords: safety efficacy; efficacy otaplimastat; otaplimastat patients; stroke ... See more keywords
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Safety and efficacy of intravenous thrombolytic treatment in wake‐up stroke: Experiences from a single center

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Published in 2021 at "Brain and Behavior"

DOI: 10.1002/brb3.2152

Abstract: Wake‐up stroke is an important clinical problem that may account for a quarter of all ischemic strokes. This study aimed to establish the safety and efficacy of intravenous thrombolytic treatment of wake‐up strokes by comparing… read more here.

Keywords: safety efficacy; efficacy intravenous; treatment; wake ... See more keywords
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Impact of IgG Fc‐Oligosaccharides on Recombinant Monoclonal Antibody Structure, Stability, Safety, and Efficacy

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Published in 2017 at "Biotechnology Progress"

DOI: 10.1002/btpr.2498

Abstract: Glycosylation of the conserved asparagine residue in the CH2 domain is the most common posttranslational modification of recombinant monoclonal antibodies. Ideally, a consistent oligosaccharide profile should be maintained from early clinical material to commercial material… read more here.

Keywords: impact; safety efficacy; safety; recombinant monoclonal ... See more keywords
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Safety and efficacy profile of cyclin‐dependent kinases 4/6 inhibitor palbociclib in cancer therapy: A meta‐analysis of clinical trials

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Published in 2019 at "Cancer Medicine"

DOI: 10.1002/cam4.1970

Abstract: Palbociclib is a small‐molecule, cyclin‐dependent kinase 4 and 6 inhibitor, which prevents phosphorylation of the retinoblastoma (Rb) protein and inhibits cell‐cycle progression from G1 to S phase. We performed this meta‐analysis to estimate the safety… read more here.

Keywords: cyclin dependent; safety efficacy; clinical trials; palbociclib cancer ... See more keywords
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Safety and efficacy of ulnar artery approach for percutaneous cardiac catheterization: Systematic review and meta‐analysis

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Published in 2018 at "Catheterization and Cardiovascular Interventions"

DOI: 10.1002/ccd.27479

Abstract: Trans‐radial access has rapidly become the standard for percutaneous coronary procedures in the last decade. As proceduralists overcome the learning curve and become more competent in trans‐radial access, alternative safe access sites such as the… read more here.

Keywords: artery; safety efficacy; efficacy ulnar; cardiac catheterization ... See more keywords
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Long‐term clinical safety and efficacy of drug‐coated balloon in the treatment of in‐stent restenosis: A meta‐analysis and systematic review

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Published in 2019 at "Catheterization and Cardiovascular Interventions"

DOI: 10.1002/ccd.28572

Abstract: The aim of this study was to evaluate the long‐term clinical safety and efficacy of drug‐coated balloon (DCB) in the treatment of in‐stent restenosis (ISR). read more here.

Keywords: term clinical; efficacy drug; long term; safety efficacy ... See more keywords
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Safety and efficacy of drug‐coated balloon for peripheral artery revascularization—A systematic review and meta‐analysis

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Published in 2022 at "Catheterization and Cardiovascular Interventions"

DOI: 10.1002/ccd.30074

Abstract: The relative merits of the drug‐coated balloon (DCB) versus uncoated balloon (UCB) angioplasty in endovascular intervention for patients with symptomatic lower extremity peripheral arterial disease (PAD) remains controversial. read more here.

Keywords: balloon; safety efficacy; coated balloon; drug coated ... See more keywords
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Safety and efficacy of transcatheter mitral valve repair in patients with COPD; results from real‐world cohort

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Published in 2022 at "Catheterization and Cardiovascular Interventions"

DOI: 10.1002/ccd.30238

Abstract: To evaluate the safety and efficacy of transcatheter mitral valve repair (TMVR) in patients with chronic obstructive pulmonary disease (COPD). read more here.

Keywords: efficacy transcatheter; valve repair; safety efficacy; mitral valve ... See more keywords
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Feasibility, safety, and efficacy of Atrial Flow Regulator in children under 10 kg

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Published in 2022 at "Catheterization and Cardiovascular Interventions"

DOI: 10.1002/ccd.30536

Abstract: The Atrial Flow Regulator (AFR) is a new self‐expandable percutaneous‐delivered fenestrated device providing an interatrial shunt. Its use in pediatric population has been reported in failing Fontan, pulmonary hypertension, or in patients with cardiomyopathy and… read more here.

Keywords: atrial flow; flow regulator; feasibility safety; safety efficacy ... See more keywords
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Long‐term safety and efficacy of left atrial appendage closure in patients with small appendage orifices measured with transesophageal echocardiography

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Published in 2022 at "Clinical Cardiology"

DOI: 10.1002/clc.23950

Abstract: The Watchman device is the most widely used occluder but is indicated in atrial fibrillation (AF) patients with a maximal left atrial appendage (LAA) orifice diameter between 17 and 31 mm. We aimed to compare the… read more here.

Keywords: long term; term safety; safety efficacy; atrial appendage ... See more keywords