Safety profile of avelumab in patients with advanced solid tumors: A pooled analysis of data from the phase 1 JAVELIN solid tumor and phase 2 JAVELIN Merkel 200 clinical trials
Sign Up to like & getrecommendations! Published in 2018 at "Cancer"
DOI: 10.1002/cncr.31293
Abstract: Antibodies targeting the programmed death‐ligand 1 (PD‐L1)/programmed cell death protein 1 (PD‐1) checkpoint may cause adverse events (AEs) that are linked to the mechanism of action of this therapeutic class and unique from those observed… read more here.
Keywords: phase; safety profile; avelumab patients; phase javelin ... See more keywords
Insight in the safety profile of antidiabetic agents glucagon‐like peptide‐1 agonists and dipeptidyl peptidase‐4 inhibitors in daily practice from the patient perspective
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DOI: 10.1002/pds.5077
Abstract: The primary aim of this study was to gain insight in the safety profile of the new antidiabetic agents glucagon‐like peptide‐1 (GLP‐1) agonists and dipeptidyl peptidase‐4 (DPP‐4) inhibitors in daily practice. The secondary aim was… read more here.
Keywords: safety profile; safety; insight safety; practice ... See more keywords
Comparison of the short-term effectiveness and safety profile of ab interno combined trabeculotomy using 2 types of trabecular hooks
Sign Up to like & getrecommendations! Published in 2020 at "Japanese Journal of Ophthalmology"
DOI: 10.1007/s10384-020-00750-3
Abstract: To compare the short-term surgical effectiveness and safety profile of ab interno trabeculotomy using 2 types of trabecular hooks. Retrospective comparative study. A retrospective chart review was performed on Japanese open-angle glaucoma patients who underwent… read more here.
Keywords: effectiveness safety; safety profile; time; medication ... See more keywords
Biological activity and safety profile of monoterpenes against Plutella xylostella L. (Lepidoptera: Plutellidae)
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-08751-y
Abstract: Plutella xylostella L. is a cosmopolitan pest of wild and cultivated crucifer vegetables worldwide. It has developed resistance to almost all commercial chemicals, making them one of the most problematic field pests in China. The… read more here.
Keywords: biological activity; safety profile; activity safety; plutella xylostella ... See more keywords
Safety Profile of Finasteride: Distribution of Adverse Effects According to Structural and Informational Dichotomies of the Mind/Brain
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DOI: 10.1007/s40261-017-0501-8
Abstract: Finasteride is currently used extensively for male androgenic alopecia and benign prostatic hyperplasia; however, some adverse effects are severe and even persistent after treatment cessation, the so-called ‘post-finasteride syndrome’. The following most severe adverse effects—sexual… read more here.
Keywords: safety profile; distribution adverse; informational dichotomies; adverse effects ... See more keywords
Analgesic and anti-inflammatory effects and safety profile of Cucurbita maxima and Cucumis sativus seeds
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.04.020
Abstract: The premise of the pharmacology of natural product is to explore benefits of natural resources for the mankind. Medicines extracted from natural resources are considered as primary source for drug discovery. Thus, the current study… read more here.
Keywords: anti inflammatory; sativus; safety profile; maxima ... See more keywords
Evaluation of the safety profile of an electronic vapour product used for two years by smokers in a real‐life setting
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DOI: 10.1016/j.yrtph.2017.12.010
Abstract: ABSTRACT The safety profile of Puritane™, a closed system electronic vapour product (EVP), was evaluated when used by smokers of conventional cigarettes (CCs) for 24 months in a real‐life setting. The study was a two‐centre… read more here.
Keywords: electronic vapour; safety profile; safety; vapour product ... See more keywords
Characterizing real world safety profile of oral Janus kinase inhibitors among adult atopic dermatitis patients: evidence transporting from the rheumatoid arthritis population
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DOI: 10.1080/03007995.2022.2088715
Abstract: Abstract Objective To address potential safety concerns of Janus Kinase Inhibitors (JAK-Is), we characterized their safety profile in the atopic dermatitis (AD) patient population. Methods In this retrospective observational study, we used propensity score-based methods… read more here.
Keywords: safety; kinase inhibitors; cohort; safety profile ... See more keywords
The safety profile of denosumab in oncology beyond the safety of denosumab as an anti-osteoporotic agent: still more to learn
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DOI: 10.1080/14740338.2021.1861246
Abstract: ABSTRACT Introduction Initially endorsed as an antiosteoporotic agent, denosumab ‒ human monoclonal antibody inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)‒ has currently shown an anticancer potential, rationalizing its exploitation in oncology. A… read more here.
Keywords: agent; safety profile; safety; oncology ... See more keywords
Ten years-experience of sunitinib in the treatment of advanced pan-NETs: an update on safety profile.
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DOI: 10.1080/14740338.2022.2000964
Abstract: INTRODUCTION Sunitinib still represent a milestone in the treatment for progressive, well-differentiated, advanced panNETs. AREAS COVERED We performed an evidence reappraisal to critically discuss its safety profile. We included 9 studies, five clinical trials and… read more here.
Keywords: real world; safety profile; treatment; safety ... See more keywords
Safety profile of lasmiditan in patients with migraine in an Asian population
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2022.2087630
Abstract: ABSTRACT Background MONONOFU, a multicenter, randomized, double-blind, placebo-controlled phase 2 study of Japanese patients with migraine, was pivotal for lasmiditan approval in Japan. However, treatment-emergent adverse events (TEAEs) were more common than in global studies.… read more here.
Keywords: safety; patients migraine; profile lasmiditan; teaes ... See more keywords