Safety profile of avelumab in patients with advanced solid tumors: A pooled analysis of data from the phase 1 JAVELIN solid tumor and phase 2 JAVELIN Merkel 200 clinical trials
Sign Up to like & getrecommendations! Published in 2018 at "Cancer"
DOI: 10.1002/cncr.31293
Abstract: Antibodies targeting the programmed death‐ligand 1 (PD‐L1)/programmed cell death protein 1 (PD‐1) checkpoint may cause adverse events (AEs) that are linked to the mechanism of action of this therapeutic class and unique from those observed… read more here.
Keywords: phase; safety profile; avelumab patients; phase javelin ... See more keywords
Safety profile of hypnotics or sedatives on community‐dwelling older adults aged 75 or older in Japan: A retrospective propensity‐matched cohort study
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.6085
Abstract: The purpose of the study is to assess if daily use of hypnotics increases mortality, aspiration pneumonia and hip fracture among relatively healthy individuals aged 75 years or older who lead independent lives in the… read more here.
Keywords: safety profile; profile hypnotics; community; study ... See more keywords
Insight in the safety profile of antidiabetic agents glucagon‐like peptide‐1 agonists and dipeptidyl peptidase‐4 inhibitors in daily practice from the patient perspective
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.5077
Abstract: The primary aim of this study was to gain insight in the safety profile of the new antidiabetic agents glucagon‐like peptide‐1 (GLP‐1) agonists and dipeptidyl peptidase‐4 (DPP‐4) inhibitors in daily practice. The secondary aim was… read more here.
Keywords: safety profile; safety; insight safety; practice ... See more keywords
Comparison of the short-term effectiveness and safety profile of ab interno combined trabeculotomy using 2 types of trabecular hooks
Sign Up to like & getrecommendations! Published in 2020 at "Japanese Journal of Ophthalmology"
DOI: 10.1007/s10384-020-00750-3
Abstract: To compare the short-term surgical effectiveness and safety profile of ab interno trabeculotomy using 2 types of trabecular hooks. Retrospective comparative study. A retrospective chart review was performed on Japanese open-angle glaucoma patients who underwent… read more here.
Keywords: effectiveness safety; safety profile; time; medication ... See more keywords
Biological activity and safety profile of monoterpenes against Plutella xylostella L. (Lepidoptera: Plutellidae)
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-08751-y
Abstract: Plutella xylostella L. is a cosmopolitan pest of wild and cultivated crucifer vegetables worldwide. It has developed resistance to almost all commercial chemicals, making them one of the most problematic field pests in China. The… read more here.
Keywords: biological activity; safety profile; activity safety; plutella xylostella ... See more keywords
Advancing Ocular Safety Profile Assessment: A Novel Grading Scale for Ocular Adverse Reactions Associated with Bemarituzumab
Sign Up to like & getrecommendations! Published in 2025 at "Ophthalmology and Therapy"
DOI: 10.1007/s40123-025-01139-6
Abstract: Targeted cancer therapies have transformed the landscape of cancer treatments but are often associated with off-target adverse drug reactions due to overlapping molecular pathways in healthy tissues, including those in the eye. Fibroblast growth factor… read more here.
Keywords: ocular adverse; adverse reactions; grading scale; safety profile ... See more keywords
Safety Profile of Finasteride: Distribution of Adverse Effects According to Structural and Informational Dichotomies of the Mind/Brain
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Drug Investigation"
DOI: 10.1007/s40261-017-0501-8
Abstract: Finasteride is currently used extensively for male androgenic alopecia and benign prostatic hyperplasia; however, some adverse effects are severe and even persistent after treatment cessation, the so-called ‘post-finasteride syndrome’. The following most severe adverse effects—sexual… read more here.
Keywords: safety profile; distribution adverse; informational dichotomies; adverse effects ... See more keywords
The Safety Profile of Pridopidine, a Novel Sigma-1 Receptor Agonist for the Treatment of Huntington’s Disease
Sign Up to like & getrecommendations! Published in 2025 at "CNS Drugs"
DOI: 10.1007/s40263-025-01171-x
Abstract: Huntington’s disease (HD) is a rare, fatal, chronic progressive neurodegenerative disorder with a significant unmet medical need for effective treatments. Pridopidine is a novel, first-in-class, highly selective and potent sigma-1 receptor (S1R) agonist in development… read more here.
Keywords: disease; profile pridopidine; profile; safety profile ... See more keywords
Analgesic and anti-inflammatory effects and safety profile of Cucurbita maxima and Cucumis sativus seeds
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.04.020
Abstract: The premise of the pharmacology of natural product is to explore benefits of natural resources for the mankind. Medicines extracted from natural resources are considered as primary source for drug discovery. Thus, the current study… read more here.
Keywords: anti inflammatory; sativus; safety profile; maxima ... See more keywords
Evaluation of the safety profile of an electronic vapour product used for two years by smokers in a real‐life setting
Sign Up to like & getrecommendations! Published in 2018 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.12.010
Abstract: ABSTRACT The safety profile of Puritane™, a closed system electronic vapour product (EVP), was evaluated when used by smokers of conventional cigarettes (CCs) for 24 months in a real‐life setting. The study was a two‐centre… read more here.
Keywords: electronic vapour; safety profile; safety; vapour product ... See more keywords
Characterizing real world safety profile of oral Janus kinase inhibitors among adult atopic dermatitis patients: evidence transporting from the rheumatoid arthritis population
Sign Up to like & getrecommendations! Published in 2022 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2022.2088715
Abstract: Abstract Objective To address potential safety concerns of Janus Kinase Inhibitors (JAK-Is), we characterized their safety profile in the atopic dermatitis (AD) patient population. Methods In this retrospective observational study, we used propensity score-based methods… read more here.
Keywords: safety; kinase inhibitors; cohort; safety profile ... See more keywords