An update on phosphate binders for the treatment of hyperphosphatemia in chronic kidney disease patients on dialysis: a review of safety profiles
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2022.2044472
Abstract: ABSTRACT Introduction Hyperphosphatemia is an inevitable complication for patients undergoing dialysis, as is the resulting need for treatment with phosphate binders. Currently, various phosphate binders are clinically available. In addition to their phosphate-lowering activity, individual… read more here.
Keywords: phosphate; hyperphosphatemia; safety profiles; treatment ... See more keywords
Differences in safety profiles of anti-herpesvirus medications: a real-world pharmacovigilance study based on the FAERS database
Sign Up to like & getrecommendations! Published in 2024 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2024.2412235
Abstract: ABSTRACT Background Anti-herpesvirus drug safety profiles have not been systematically compared. Understanding variations in adverse events (AEs) could provide reference for rational clinical use. Methods We collected data on acyclovir, ganciclovir, valaciclovir, and foscarnet from… read more here.
Keywords: faers database; ror; foscarnet; anti herpesvirus ... See more keywords
a comparative analysis of the safety profiles between inclisiran and other PCSK9 inhibitors from real-world evidence- what have we learned recently?
Sign Up to like & getrecommendations! Published in 2024 at "Expert opinion on drug safety"
DOI: 10.1080/14740338.2024.2438753
Abstract: BACKGROUND Inclisiran is a novel inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9). This study aimed to explore its safety profiles through real-world research. RESEARCH DESIGN AND METHODS Reports from FDA Adverse Event Reporting System… read more here.
Keywords: real world; pcsk9 inhibitors; comparative analysis; safety ... See more keywords
Review of the Safety Profiles of Laxatives in Pregnant Women
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Gastroenterology"
DOI: 10.1097/mcg.0000000000001660
Abstract: Chronic constipation is one of the most common complaints seen in the gastroenterology clinic and is particularly prevalent in women. Women who become pregnant may suffer from existing constipation or develop constipation de novo. A… read more here.
Keywords: constipation; gastroenterology; profiles laxatives; safety ... See more keywords
Efficacy and safety profiles of mood stabilizers and antipsychotics for bipolar depression: a systematic review
Sign Up to like & getrecommendations! Published in 2023 at "International Clinical Psychopharmacology"
DOI: 10.1097/yic.0000000000000449
Abstract: The whole picture of psychotropics for bipolar depression (BPD) remains unclear. This review compares the differences in efficacy and safety profiles among common psychotropics for BPD. MEDLINE, EMBASE, and PsycINFO were searched for proper studies.… read more here.
Keywords: efficacy safety; efficacy; bipolar depression; safety profiles ... See more keywords
HRA00129-C004, a Novel c-Met Antibody-Drug Conjugate (ADC), Exerts Encouraging Anti-Tumor Activities and Favorable Safety Profiles.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-24-0680
Abstract: The c-Met receptor tyrosine kinase, encoded by the MET proto-oncogene, plays a critical role in embryogenesis, tissue regeneration and carcinogenesis. It is predominantly expressed in neoplastic cells and essential for tumor growth and metastasis, making… read more here.
Keywords: hra00129 c004; tumor; antibody drug; anti tumor ... See more keywords
Abstract LB031: SHR-A1811, a novel anti-HER2 ADC with superior bystander effect, optimal DAR and favorable safety profiles
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb031
Abstract: Current clinical HER2-targeting ADCs, especially T-DXd, have shown strong efficacy in HER2-expressing/mutant cancers, however, with adverse events such as hematologic toxicities and interstitial lung disease (ILD)/pneumonitis. Here we presented a potential best-in-class HER2-directed ADC, SHR-A1811,… read more here.
Keywords: safety profiles; shr a1811; cancer; her2 ... See more keywords
Comparative quantitative safety profiles of PD-1 and PD-L1 checkpoint inhibitor monotherapies: A Bayesian model-based meta-analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e15167
Abstract: e15167Background: Anti-cancer therapies with immune checkpoint inhibitors (ICIs) are associated with immune-mediated adverse events (imAEs). The objective of this study was to use a Bayesian model-... read more here.
Keywords: safety profiles; bayesian model; model; quantitative safety ... See more keywords
SHR-A1811, a novel anti-HER2 antibody–drug conjugate with optimal drug-to-antibody ratio, efficient tumor killing potency, and favorable safety profiles
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DOI: 10.1371/journal.pone.0326691
Abstract: HER2-targeting antibody–drug conjugates (ADCs), especially trastuzumab deruxtecan (T-DXd), have revolutionized the treatment landscape of HER2-expressing or mutant cancers. However, undesired adverse events are still inevitable and it is necessary to discover a HER2-directed ADC with… read more here.
Keywords: shr a1811; anti her2; drug; her2 ... See more keywords
Predictive Value of Albumin and Neutrophil-to-Lymphocyte Ratio Score for Treatment Completeness and Safety Profiles in Patients With Head and Neck Cancer Receiving Definitive Concurrent Chemoradiotherapy
Sign Up to like & getrecommendations! Published in 2022 at "In Vivo"
DOI: 10.21873/invivo.13028
Abstract: Abstract Background/Aim: Malnutrition and inflammation are common conditions in patients with head and neck cancer (HNC). This study aimed to evaluate the predictive value of albumin combined with neutrophil-lymphocyte ratio (NLR), referring to the albumin-NLR… read more here.
Keywords: completeness; treatment completeness; value; safety profiles ... See more keywords
Molecular Insights of SARS-CoV-2 Antivirals Administration: A Balance between Safety Profiles and Impact on Cardiovascular Phenotypes
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020437
Abstract: The COVID-19 pandemic has resulted in a complex clinical challenge, caused by a novel coronavirus, partially similar to previously known coronaviruses but with a different pattern of contagiousness, complications, and mortality. Since its global spread,… read more here.
Keywords: safety profiles; impact cardiovascular; molecular insights; administration ... See more keywords