Structure-based antigenic epitope and PEGylation improve the efficacy of staphylokinase
Sign Up to like & getrecommendations! Published in 2017 at "Microbial Cell Factories"
DOI: 10.1186/s12934-017-0801-y
Abstract: Staphylokinase (Sak) holds promise for use in thrombolytic therapy for acute myocardial infarction. However, its immunogenicity is a major disadvantage under clinical conditions. PEGylation has become a sophisticated method to decrease that immunogenicity. In this… read more here.
Keywords: sak; peg sak; sak c104r; pegylation ... See more keywords
Protective effect of sakuranetin in brain cells of dementia model rats.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2019.65.5.9
Abstract: Alzheimer's disease (AD) is a high-incidence neurodegenerative disease with complex and diverse pathogenesis. With aging of the population and continuous improvement of living standards, the incidence of AD is on the increase. Therefore, there is… read more here.
Keywords: sak; sakuranetin; effect; model ... See more keywords
Cloning & expression of SAK enzyme from Staphylococcus aureus in E. coli BL21-CodonPlus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicine and Life"
DOI: 10.25122/jml-2021-0335
Abstract: Staphylokinase (SAK), also known as staphylococcal fibrinolysin, is a protein with a molecular mass of about 15 kDa produced by Staphylococcus aureus. Staphylokinase is synthesized in the late exponential phase, similar to streptokinase. The current… read more here.
Keywords: staphylococcus aureus; sak; cloning expression; expression sak ... See more keywords