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Salicylate metal-binding isosteres as fragments for metalloenzyme inhibition

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1 Published in 2022 at "Chemical Science"

DOI: 10.1039/d1sc06011b

Abstract: Metalloenzyme inhibitors typically share a common need to possess a metal-binding pharmacophore (MBP) for binding the active site metal ions. However, MBPs can suffer from physicochemical liabilities, impeding the pharmacological properties and drug-likeliness of inhibitors.… read more here.

Keywords: inhibition; salicylate metal; activity; binding isosteres ... See more keywords