Semi-synthetic salinomycin analogs exert cytotoxic activity against human colorectal cancer stem cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.147
Abstract: Salinomycin, a polyether antibiotic, is a well-known inhibitor of human cancer stem cells. Chemical modification of the allylic C20 hydroxyl of salinomycin has enabled access to synthetic analogs that display increased cytotoxic activity compared to… read more here.
Keywords: cancer stem; colorectal cancer; human colorectal; cancer ... See more keywords
A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.12.057
Abstract: Tumors are phenotypically heterogeneous and include a small sub-population of cancer cells (2-5% of the tumor mass) with stem-cell like properties. The cancer stem cell hypothesis postulates that the cancer stem cells (CSCs) show the… read more here.
Keywords: cscs; medicinal chemistry; chemistry; cancer cells ... See more keywords
Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c04082
Abstract: Salinomycin exhibits significant systemic adverse reactions such as tachycardia and myoglobinuria in mammals, which hinders its application as a drug for human cancers. Although many strategies aimed at increasing salinomycin’s toxicity to cancer cells have… read more here.
Keywords: cancer; cytotoxicity; salinomycin; targeting telomerase ... See more keywords
Salinomycin induces autophagic cell death in salinomycin-sensitive melanoma cells through inhibition of autophagic flux
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-75598-1
Abstract: Several literature has shown that salinomycin (Sal) is able to kill various types of cancer cells through different signaling pathways. However, its effect on melanoma has seldom been reported. We examined the anti-cancer efficacy of… read more here.
Keywords: melanoma; sal; cell death; salinomycin ... See more keywords
Effects of encapsulated butyrate and salinomycin on gut leakage and intestinal inflammation in broilers
Sign Up to like & getrecommendations! Published in 2022 at "British Poultry Science"
DOI: 10.1080/00071668.2022.2042483
Abstract: ABSTRACT 1. The objectives of this study were to i) compare the effects of a commercial product providing encapsulated butyrate (EB) in combination with salinomycin in diets of broilers with impaired intestinal integrity and ii)… read more here.
Keywords: gut; intestinal integrity; encapsulated butyrate; salinomycin ... See more keywords
Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2,9 via AMPK-SIRT1 pathway in a non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/1393003.congress-2017.pa3303
Abstract: The antibiotic salinomycin was recently identified as an antitumor drug for the treatment of several types of solid tumors. However, the effects of salinomycin on the migratory and invasive properties of non-small cell lung cancer… read more here.
Keywords: tgf induced; induced emt; lung cancer; salinomycin ... See more keywords
Salinomycin repressed the epithelial–mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway
Sign Up to like & getrecommendations! Published in 2017 at "OncoTargets and therapy"
DOI: 10.2147/ott.s126463
Abstract: Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological malignancies. Most patients are diagnosed in the advanced stage and have distant metastasis ultimately. Salinomycin has been demonstrated to reduce invasive capacity… read more here.
Keywords: catenin; catenin pathway; salinomycin could; salinomycin ... See more keywords
The combination therapy of salinomycin and gefitinib using poly(d,l-lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles for targeting both lung cancer stem cells and cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "OncoTargets and therapy"
DOI: 10.2147/ott.s141083
Abstract: Purpose Lung cancer (LC) is the leading cause of cancer death worldwide. Evidences suggest that both LC cancer stem cells (CSCs) and cancer cells are supposed to be eliminated to achieve superior treatment effect against… read more here.
Keywords: salinomycin nps; gefitinib nps; cancer cells; cancer ... See more keywords