Pilocarpine-Induced Effects on Salivary Secretion as a Pharmacological Biomarker for Cholinergic Parasympathetic Activation.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1048
Abstract: Pilocarpine-induced salivary secretion could serve as a nontherapeutic target engagement biomarker in a clinical setting to test the activity of an M3 positive allosteric modulator (PAM). The potentiating effect on the reactivity of the M3… read more here.
Keywords: pilocarpine; pilocarpine induced; induced effects; effects salivary ... See more keywords
Hyperoxia reduces salivary secretion by inducing oxidative stress in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2018.11.001
Abstract: OBJECTIVE The aim of this study was to determine the effects of prolonged hyperoxia on salivary glands and salivary secretion in mice. DESIGN Male C57BL/6 J mice were kept in a 75% oxygen chamber (hyperoxia group)… read more here.
Keywords: secretion; hyperoxia; mice; salivary secretion ... See more keywords
Alteration of myoepithelial cells during botulinum toxin type A-inhibited salivary secretion.
Sign Up to like & getrecommendations! Published in 2023 at "Oral diseases"
DOI: 10.1111/odi.14576
Abstract: OBJECTIVE Intraglandular injection of botulinum toxin type A (BoNT/A) effectively treats sialorrhea. Myoepithelial cells (MECs) are essential for salivary secretion. The role of MECs in BoNT/A-inhibited salivary secretion and its underlying mechanisms remain unknown. MATERIALS… read more here.
Keywords: salivary secretion; inhibited salivary; myoepithelial cells; secretion ... See more keywords
Simultaneous monitoring of Ca2+ responses and salivary secretion in live animals reveals a threshold intracellular Ca2+ concentration for salivation
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Physiology"
DOI: 10.1113/ep086868
Abstract: What is the central question of this study? The effects of Ca2+ responses on salivary fluid secretion have been studied indirectly by monitoring ion channel activities and other indices. Therefore, Ca2+ responses during salivary secretion… read more here.
Keywords: responses salivary; ca2 responses; salivary secretion; secretion ... See more keywords
A Stimulator of the Salivary Excretion Based on Physical Vibration of the Parotid Glands
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/8252170
Abstract: Oral dryness causes significant health problems both functional (difficulty speaking, chewing and swallowing) and structural in teeth (increased number of infections) and oral mucosa. The main objective of this study is to show an alternative… read more here.
Keywords: salivary secretion; salivary excretion; excretion based; based physical ... See more keywords