SALL4 correlates with proliferation, metastasis, and poor prognosis in prostate cancer by affecting MAPK pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5998
Abstract: BACKGROUND The mechanism involved in prostate cancer (PCa) metastasis is still poorly understood, and several oncogenes are known to regulate this process. However, the role of spalt-like transcription factor 4 (SALL4) in PCa metastasis remains… read more here.
Keywords: metastasis; prostate cancer; pca; expression ... See more keywords
Correlation between SALL4 stemness marker and bone morphogenetic protein signaling genes in esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22262
Abstract: SALL4, as a stemness marker, plays a key role in the maintenance of pluripotency and self‐renewal of cancer stem cells. To elucidate probable linkage between SALL4 stemness marker and bone morphogenetic protein (BMP) cell signaling… read more here.
Keywords: sall4; cell; stemness marker; sall4 stemness ... See more keywords
Long noncoding HOXA11-AS knockdown suppresses the progression of non-small cell lung cancer by regulating miR-3619-5p/SALL4 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular histology"
DOI: 10.1007/s10735-021-09981-1
Abstract: Accumulating evidence suggested that many long noncoding RNAs (lncRNAs) were widely involved in the development and progression of non-small cell lung cancer (NSCLC). However, the roles of lncRNA homeobox A11 antisense (HOXA11-AS) and its underlying… read more here.
Keywords: sall4; hoxa11; mir 3619; hoxa11 knockdown ... See more keywords
SALL4 mediates SHP2 inhibition in myocardial fibroblasts through the DOT1L/H3K79me2 signaling pathway to promote the progression of myocardial infarction
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-81815-y
Abstract: Objective: To explore the influence of SALL4 in cardiac fibroblasts on the progression of myocardial infarction. Methods: Analysis of genes specifically expressed in myocardial infarction by bioinformatics methods; The impact of SALL4 on myocardial infarction… read more here.
Keywords: cardiac fibroblasts; sall4; infarction; myocardial infarction ... See more keywords
USP37-stabilized SALL4 promotes the keloid formation by PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-91776-5
Abstract: Spalt-like transcription factor 4 (SALL4) plays a vital role in the progression of many human diseases. However, the role and mechanism of SALL4 regulates in keloid formation remain unclear. The mRNA levels of SALL4 and… read more here.
Keywords: sall4; akt pathway; keloid formation; keloid fibroblast ... See more keywords
MDB-29. SALL4 IS A CRL3REN/KCTD11 SUBSTRATE THAT DRIVES SONIC HEDGEHOG-DEPENDENT MEDULLOBLASTOMA
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae064.478
Abstract: Abstract BACKGROUND Medulloblastoma (MB) is the most common malignant pediatric brain tumor arising from alterations in cerebellum development. The Sonic Hedgehog variant (SHH MB) is the best genetically characterized, however the molecular mechanisms responsible for… read more here.
Keywords: sall4; sall4 crl3ren; shh; substrate ... See more keywords
Production and characterization of a new specific monoclonal antibody against A‐isoform of SALL4: A novel emerging testicular cancer marker
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14608
Abstract: SALL4 transcription factor plays an important role to maintain the pluripotent and self‐renewal of embryonic stem cells. It contributes to the growth of many cancers and embryonic development. With the exception of spermatogonia, SALL4 expression… read more here.
Keywords: isoform sall4; isoform; sall4; testicular cancer ... See more keywords
PO-160 Downregulation of the oncofetal gene SALL4 in melanoma leads to invasion and metastasis by differential acetylation mediated through binding to HDACs
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.199
Abstract: Introduction The transcription factor Sall4 is a well-known developmental regulator involved in embryonic patterning and stem cell maintenance. More recently Sall4 has been suggested to be an oncofetal gene due to being expressed in many… read more here.
Keywords: melanoma; acetylation; oncofetal gene; sall4 ... See more keywords
Targeting SALL4 with an HLA Class I-restricted TCR for cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-24-0207
Abstract: Aberrant expression of the oncogene SALL4 is associated with stemness, more aggressive cancer phenotype, and reduced patient survival in various tumor types making SALL4 a potential target for cancer immunotherapy. We conducted a transcriptional analysis… read more here.
Keywords: cancer; hla; sall4; cancer immunotherapy ... See more keywords
Role of SALL4 in HER2+ Breast Cancer Progression: Regulating PI3K/AKT Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113292
Abstract: Treatment for the HER2+ breast cancer subtype is still unsatisfactory, despite breakthroughs in research. The discovery of various new molecular mechanisms of transcription factors may help to make treatment regimens more effective. The transcription factor… read more here.
Keywords: her2; expression; sall4; breast cancer ... See more keywords