A salt bridge of the C‐terminal carboxyl group regulates PHPT1 substrate affinity and catalytic activity
Sign Up to like & getrecommendations! Published in 2024 at "Protein Science"
DOI: 10.1002/pro.5009
Abstract: PHPT1 is a histidine phosphatase that modulates signaling in eukaryotes through its catalytic activity. Here, we present an analysis of the structure and dynamics of PHPT1 through a combination of solution NMR, molecular dynamics, and… read more here.
Keywords: catalytic activity; salt bridge; terminal carboxyl; carboxyl group ... See more keywords
Totally transparent hydrogel-based subdural electrode with patterned salt bridge.
Sign Up to like & getrecommendations! Published in 2020 at "Biomedical microdevices"
DOI: 10.1007/s10544-020-00517-0
Abstract: A totally transparent subdural electrode was developed by embedding a conductive poly (vinyl alcohol) (PVA)-filled microchannel made of poly(dimethylsiloxane) (PDMS) into an another PVA hydrogel substrate. Tight bonding between the PVA substrate and the PDMS… read more here.
Keywords: electrode; hydrogel; salt bridge; subdural electrode ... See more keywords
Curcumin Dictates Divergent Fates for the Central Salt Bridges in Amyloid-β40 and Amyloid-β42.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.02.043
Abstract: There are three specific regions in the Amyloid beta (Aβ) peptide sequence where variations cause enhanced toxicity in Alzheimer's disease: the N-terminus, the central salt bridge, and the C-terminus. Here, we investigate if there is… read more here.
Keywords: salt; central salt; toxicity; salt bridge ... See more keywords
Accurate Description of Solvent-Exposed Salt Bridges with a Non-polarizable Force Field Incorporating Solvent Effects
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00678
Abstract: The strength of salt bridges resulting from the interaction of cations and anions is modulated by their environment. However, polarization of the solvent molecules by the charged moieties makes the accurate description of cation-anion interactions… read more here.
Keywords: salt bridge; solvent; force field; salt ... See more keywords
Salt-Bridge-Mediated Coacervate-to-Vesicle Transformation in Arginine-Rich Coacervates.
Sign Up to like & getrecommendations! Published in 2025 at "ACS nano"
DOI: 10.1021/acsnano.5c02235
Abstract: Polypeptide-based liquid-liquid phase separation (LLPS) has received considerable attention as it governs the formation of membraneless organelles in cells. However, the detailed mechanistic understanding of how one of the most prevalent cationic amino acids in… read more here.
Keywords: rich coacervates; arginine rich; salt bridge; transformation arginine ... See more keywords
Salt Bridge in Aqueous Solution: Strong Structural Motifs but Weak Enthalpic Effect
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31935-z
Abstract: Salt bridges are elementary motifs of protein secondary and tertiary structure and are commonly associated with structural driving force that increases stability. Often found on the interface to the solvent, they are highly susceptible to… read more here.
Keywords: aqueous solution; salt bridge; bridge aqueous; salt ... See more keywords
Intrinsic basis of thermostability of prolyl oligopeptidase from Pyrococcus furiosus
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90723-4
Abstract: Salt-bridges play a key role in the thermostability of proteins adapted in stress environments whose intrinsic basis remains to be understood. We find that the higher hydrophilicity of PfP than that of HuP is due… read more here.
Keywords: bridge; thermostability; salt bridge; intrinsic basis ... See more keywords
A cyanobacteria-derived intermolecular salt bridge stabilizes photosynthetic NDH-1 and prevents oxidative stress
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-07556-4
Abstract: Throughout evolution, addition of numerous cyanobacteria-derived subunits to the photosynthetic NDH-1 complex stabilizes the complex and facilitates cyclic electron transfer around photosystem I (PSI CET), a critical antioxidant mechanism for efficient photosynthesis, but its stabilization… read more here.
Keywords: salt bridge; derived intermolecular; cyanobacteria derived; photosynthetic ndh ... See more keywords
Salt-bridge mediated cooperativity and mechanical stabilization of tandem spectrin repeats.
Sign Up to like & getrecommendations! Published in 2025 at "Nanoscale horizons"
DOI: 10.1039/d5nh00112a
Abstract: Spectrin superfamily proteins play essential roles in cells by interlinking various cytoskeletal components and bridging the cytoskeleton to both the cell membrane and the nucleus. Characterized by the spectrin repeat (SR) domain, this superfamily features… read more here.
Keywords: bridge; cooperativity; bridge mediated; salt bridge ... See more keywords
A mechanism of salt bridge–mediated resistance to FtsZ inhibitor PC190723 revealed by a cell-based screen
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-12-0538
Abstract: Bacterial cell division proteins, especially the tubulin homolog FtsZ, have emerged as strong targets for developing new antibiotics. Here, we have utilized the fission yeast heterologous expression system to develop a cell-based assay to screen… read more here.
Keywords: pc190723; cell based; cell; resistance ... See more keywords
A Novel Salt-Bridge Electroflocculation Technology for Harvesting Microalgae
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.902524
Abstract: Microalgae biomass, as a promising alternative feedstock, can be refined into biodiesel, pharmaceutical, and food productions. However, the harvesting process for quality biomass still remains a main bottleneck due to its high energy demand. In… read more here.
Keywords: salt bridge; biomass; bridge electroflocculation;