Amide‐phosphonium Salt Catalyzed Enantioselective Vinylogous Mannich Addition of Coumarins to Isatin Imines
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DOI: 10.1002/cctc.201901677
Abstract: An asymmetric vinylogous Mannich reaction between 3‐cyano‐4‐methylcoumarins and N‐Boc isatin imines catalysed by amide phosphonium salt is described. This method allows the formation of intriguing adducts bearing both 3‐aminooxindole and coumarin moieties in excellent yields… read more here.
Keywords: isatin imines; amide phosphonium; salt catalyzed; vinylogous mannich ... See more keywords
Tetraarylphosphonium salt-catalyzed formal [3+2] cycloaddition between epoxides and trichloroacetonitrile for the synthesis of β-amino alcohol derivatives.
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DOI: 10.1039/d2cc03782c
Abstract: Efficient regioselective synthesis of β-amino alcohol derivatives, including enantioenriched ones, by a tetraarylphosphonium salt-catalyzed coupling reaction of epoxides with trichloroacetonitrile is described. Formal [3+2] cycloaddition, followed by hydrolysis, proceeded smoothly to afford N-protected β-amino alcohols… read more here.
Keywords: synthesis amino; amino alcohol; alcohol derivatives; salt catalyzed ... See more keywords
Identifying key intermediates generated in situ from Cu(II) salt–catalyzed C–H functionalization of aromatic amines under illumination
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DOI: 10.1126/sciadv.1700666
Abstract: Cu(II) salts can activate C–H bonds of aromatic amines or imines to construct C–C bonds in air without external photosensitizer. Copper compounds involved in photocatalysis have recently spurred considerable interest for their novel transformations. However,… read more here.
Keywords: key intermediates; aromatic amines; salt catalyzed; catalyzed functionalization ... See more keywords