The noncanonical nucleotide binding site 1 of the bile salt export pump is optimized for proper function of the transporter
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology International"
DOI: 10.1002/cbin.12136
Abstract: The bile salt export pump (ABCB11/BSEP) is a hepatocyte plasma membrane‐resident protein translocating bile salts into bile canaliculi. The sequence alignment of the four full‐length transporters of the ABCB subfamily (ABCB1, ABCB4, ABCB5 and ABCB11)… read more here.
Keywords: binding site; bile salt; nucleotide binding; salt export ... See more keywords
High-Throughput Assessment of Bile Salt Export Pump Inhibition Using RapidFire-MS and DESI-MS.
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DOI: 10.1021/acsmedchemlett.4c00302
Abstract: The bile salt export pump (BSEP) assay is widely used to evaluate the potential for drug-induced liver injury (DILI) early in the drug discovery process. While traditional liquid chromatography-mass spectrometry (LC-MS)-based approaches have been utilized… read more here.
Keywords: high throughput; bile salt; salt export; throughput ... See more keywords
Association between bile salt export pump polymorphisms and intrahepatic cholestasis of pregnancy susceptibility: a meta-analysis of case-control studies
Sign Up to like & getrecommendations! Published in 2019 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2018.1512570
Abstract: Abstract The purpose of this meta-analysis was to investigate the relationship between bile salt export pump (BSEP) polymorphisms and intrahepatic cholestasis of pregnancy (ICP) susceptibility. Retrieved studies from Pubmed, EMBASE, Web of Science, Cochrane Library… read more here.
Keywords: susceptibility; meta analysis; bile salt; salt export ... See more keywords
Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11
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DOI: 10.12688/f1000research.26632.1
Abstract: Background: Bile salt export pump (BSEP/ABCB11) is important in the maintenance of the enterohepatic circulation of bile acids and drugs. Drugs such as rifampicin and glibenclamide inhibit BSEP. Progressive familial intrahepatic cholestasis type-2, a lethal… read more here.
Keywords: glibenclamide atp; atp metformin; bile salt; salt export ... See more keywords