Transient Closure of a Cylindrical Hole in a Salt Formation Considered as a Norton–Hoff Medium
Sign Up to like & getrecommendations! Published in 2019 at "Rock Mechanics and Rock Engineering"
DOI: 10.1007/s00603-018-1732-6
Abstract: This paper focuses on the mechanical behavior of boreholes or elongated cylindrical salt caverns. A typical problem is as follows: a single cavern is leached out from a salt formation whose extension, when compared to… read more here.
Keywords: salt formation; salt; medium; formation considered ... See more keywords
Saturation Solubility and Dissolution Property Improvement of Albendazole by Salt Formation Approach
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DOI: 10.1007/s12247-021-09588-9
Abstract: Albendazole belongs to BCS-II category whose systemic and local anthelmintic effectiveness is restricted due to its low water solubility–related dissolution properties. The present investigation was aimed to prepare salts of albendazole using various weak organic… read more here.
Keywords: salt formation; saturation solubility; solubility dissolution; acid ... See more keywords
Expedited development of a high dose orally disintegrating metformin tablet enabled by sweet salt formation with acesulfame.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.08.100
Abstract: Salt formation has been extensively used to improve drug properties, including solubility, stability and mechanical properties. A sweet salt of metformin with acesulfame, prepared though an anion exchange reaction, showed superior properties over the commercial… read more here.
Keywords: salt formation; orally disintegrating; sweet salt; acesulfame ... See more keywords
Salt formation of two BCS II drugs (indomethacin and naproxen) with (1R, 2R)-1,2-diphenylethylenediamine: Crystal structures, solubility and thermodynamics analysis
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DOI: 10.1016/j.molstruc.2019.02.104
Abstract: Abstract Indomethacin (Indo) and naproxen (Nap) belong to Biopharmaceutical Classification System (BCS) class II drugs, which permeate membranes well but are poorly soluble. Two pharmaceutical salts hydrate of Indo and Nap with (1R,2R)-1,2-diphenylethylenediamine (DPEN) were… read more here.
Keywords: solubility thermodynamics; diphenylethylenediamine; analysis; solubility ... See more keywords
Fluorescence-Based High-Throughput Salt Screening.
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DOI: 10.1016/j.xphs.2018.02.018
Abstract: The present study reports a high-throughput screening method for the salt formation of amine-containing active pharmaceutical ingredients (APIs) based on fluorescence measurements. A free form amine API was alkynylated by a solid-vapor reaction using propargyl… read more here.
Keywords: salt formation; salt screening; salt; amine ... See more keywords
Amorphous Drug–Polymer Salts: Maximizing Proton Transfer to Enhance Stability and Release
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DOI: 10.1021/acs.molpharmaceut.2c00942
Abstract: An amorphous drug–polymer salt (ADPS) can be remarkably stable against crystallization at high temperature and humidity (e.g., 40°C/75% RH) and provide fast release. Here, we report that process conditions strongly influence the degree of proton… read more here.
Keywords: stability; salt formation; drug; drug polymer ... See more keywords
Enhancing Dissolution and Bacteriostatic Activity of Trimethoprim through Salt Formation
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DOI: 10.1039/d3ce00128h
Abstract: Trimethoprim (TMP) is a commonly used BCS class II antibiotic, the water solubility of which needs to be improved to overcome the limitations in oral administration. Herein, We combined TMP... read more here.
Keywords: trimethoprim salt; bacteriostatic activity; salt formation; enhancing dissolution ... See more keywords
Research on a probabilistic assessment criterion of casing deformation in an incomplete borehole in deep salt formation
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering"
DOI: 10.1177/0954408915605975
Abstract: Drilling and completing wells through complex salt formation is technically challenging and costing. Field data demonstrates that well casings designed by traditional safety coefficient criterion occurring failure in deep salt formation though their safety factors… read more here.
Keywords: salt formation; criterion; well casings; formation ... See more keywords