Prebiotics may alter bile salt hydrolase activity: Possible implications for cholesterol metabolism
Sign Up to like & getrecommendations! Published in 2020 at "PharmaNutrition"
DOI: 10.1016/j.phanu.2020.100182
Abstract: Abstract Probiotics secrete bile salt hydrolase (BSH) which catalyses the deconjugation and excretion of bile salts in the GI tract altering cholesterol metabolism in the liver. Many probiotic preparations include prebiotics to promote probiotic growth… read more here.
Keywords: salt; bile salt; cholesterol metabolism; activity ... See more keywords
A continuous fluorescence assay for simple quantification of bile salt hydrolase activity in the gut microbiome
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-37656-7
Abstract: The microbiota of the mammalian gut plays a dynamic role in controlling host physiology. The effect of gut microbiota activity on host health is particularly evident in the case of bile homeostasis. Bile is produced… read more here.
Keywords: bile salt; bsh; host; activity ... See more keywords
The complex structure of bile salt hydrolase from Lactobacillus salivarius reveals the structural basis of substrate specificity
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48850-6
Abstract: The gut bacterial bile salt hydrolase (BSH) plays a critical role in host lipid metabolism and energy harvest. Therefore, BSH is a promising microbiome target to develop new therapies to regulate obesity in humans and… read more here.
Keywords: bile salt; substrate; structure; salt hydrolase ... See more keywords
Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60821-w
Abstract: Ursodeoxycholic acid (UDCA) treatment can reduce itch and lower endogenous serum bile acids in intrahepatic cholestasis of pregnancy (ICP). We sought to determine how it could influence the gut environment in ICP to alter enterohepatic… read more here.
Keywords: bile salt; bile; pregnancy; salt hydrolase ... See more keywords
Microbial bile salt hydrolase activity influences gene expression profiles and gastrointestinal maturation in infant mice
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2149023
Abstract: ABSTRACT The mechanisms by which early microbial colonizers of the neonate influence gut development are poorly understood. Bacterial bile salt hydrolase (BSH) acts as a putative colonization factor that influences bile acid signatures and microbe-host… read more here.
Keywords: expression profiles; salt hydrolase; expression; activity ... See more keywords
Short Communication: Detection and expression analysis of the bile salt hydrolase gene in Pediococcus and Lactobacillus
Sign Up to like & getrecommendations! Published in 2020 at "Biodiversitas"
DOI: 10.13057/biodiv/d211255
Abstract: Abstract. Widodo, Nuratri Y, Sukarno AS, Ahyuningsih TD. 2020. Short Communication: Detection and expression analysis of the bile salt hydrolase gene in Pediococcus and Lactobacillus. Biodiversitas 21: 5901-5905. Bile salt hydrolase (BSH) has been considered… read more here.
Keywords: expression; bile; salt hydrolase; gene ... See more keywords
Bile Salt Hydrolase Degrades β-Lactam Antibiotics and Confers Antibiotic Resistance on Lactobacillus paragasseri
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.858263
Abstract: Bile salt hydrolase (BSH) is a well-characterized probiotic enzyme associated with bile detoxification and colonization of lactic acid bacteria in the human gastrointestinal tract. Here, we isolated a putative BSH (LpBSH) from the probiotic bacterium… read more here.
Keywords: lactobacillus paragasseri; salt hydrolase; resistance; bile salt ... See more keywords
In Vitro Bile Salt Hydrolase (BSH) Activity Screening of Different Probiotic Microorganisms
Sign Up to like & getrecommendations! Published in 2021 at "Foods"
DOI: 10.3390/foods10030674
Abstract: Bile salt hydrolase (BSH) activity in probiotic strains is usually correlated with the ability to lower serum cholesterol levels in hypercholesterolemic patients. The objective of this study was the evaluation of BSH in five probiotic… read more here.
Keywords: bile salt; bsh; hydrolase bsh; activity ... See more keywords
Bile Salt Hydrolase-Competent Probiotics in the Management of IBD: Unlocking the “Bile Acid Code”
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14153212
Abstract: Bile acid (BA) species and the gut microbiota (GM) contribute to intestinal mucosa homeostasis. BAs shape the GM and, conversely, intestinal bacteria with bile salt hydrolase (BSH) activity modulate the BA pool composition. The mutual… read more here.
Keywords: bile acid; salt hydrolase; bile salt;