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   Articles with "salt inducible" as a keyword



Salt inducible kinases 2 and 3 are required for thymic T cell development

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-00986-0

Abstract: Salt Inducible Kinases (SIKs), of which there are 3 isoforms, are established to play roles in innate immunity, metabolic control and neuronal function, but their role in adaptive immunity is unknown. To address this gap,… read more here.

Keywords: cell development; salt inducible; inducible kinases; thymic cell ... See more keywords

Advanced modeling of salt-inducible kinase (SIK) inhibitors incorporating protein flexibility through molecular dynamics and cross-docking

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-03699-w

Abstract: Salt-inducible kinases (SIK1, SIK2, and SIK3) regulate metabolism and immune responses, making them promising targets for inflammatory and autoimmune diseases. Understanding inhibitor selectivity among isoforms is crucial for therapeutic development. In this study, 44 compounds… read more here.

Keywords: salt inducible; protein flexibility; molecular dynamics; sik inhibitors ... See more keywords

Abstract PS4-41: Salt-inducible kinases suppress tumour function and regulate drug resistance in breast cancer

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recommendations! Published in 2021 at "Cancer Research"

DOI: 10.1158/1538-7445.sabcs20-ps4-41

Abstract: Background: Salt-inducible kinases (SIKs) belonging to an AMP-activated kinase (AMPK) family, have functions in tumourgeniesis and metastasis in many solid tumours. However, the role of SIKs in breast cancer is not clear. In this study… read more here.

Keywords: expression; salt inducible; cancer; breast cancer ... See more keywords

LKB1-Salt-Inducible Kinase Signaling Is Essential in MEF2C+ Leukemia.

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recommendations! Published in 2018 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-rw2018-044

Abstract: MEF2C activity in acute myeloid leukemia is dependent upon salt-inducible kinase (SIK) signaling. read more here.

Keywords: leukemia; inducible kinase; mef2c; salt inducible ... See more keywords

The Role of the Salt-Inducible Kinases in the Endocrine Glands.

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recommendations! Published in 2025 at "Endocrinology"

DOI: 10.1210/endocr/bqaf100

Abstract: The salt-inducible kinases (SIKs), a family of serine/threonine kinases, are emerging endocrine regulators. The three isoforms, SIK1, SIK2, and SIK3, compose a subfamily of the AMPK-related kinases. The SIKs have multiple conserved protein kinase A… read more here.

Keywords: salt inducible; role salt; inducible kinases; endocrine glands ... See more keywords

Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0185426

Abstract: Osteoclasts are large multinucleated cells responsible for bone resorption. Excessive inflammatory activation of osteoclasts leads to bony erosions, which are the hallmark of several diseases such as rheumatoid arthritis (RA). Salt-inducible kinases (SIK) constitute a… read more here.

Keywords: sik inhibition; inhibition; salt inducible; inducible kinases ... See more keywords

Expression of a Tagless Single-Chain Variable Fragment (scFv) of Anti-TNF-α by a Salt Inducible System and its Purification and Characterization.

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recommendations! Published in 2021 at "Protein and peptide letters"

DOI: 10.2174/0929866528666210922141402

Abstract: BACKGROUND Anti-TNF-α scFv is gaining acceptance as an effective drug for various diseases such as rheumatoid arthritis and Crohn's disease that involve elevated levels of TNF-α. The single-chain variable fragment (scFv) consists of variable regions… read more here.

Keywords: scfv; anti tnf; inducible system; salt inducible ... See more keywords

Understanding the roles of salt-inducible kinases in cardiometabolic disease

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recommendations! Published in 2024 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2024.1426244

Abstract: Salt-inducible kinases (SIKs) are serine/threonine kinases of the adenosine monophosphate-activated protein kinase family. Acting as mediators of a broad array of neuronal and hormonal signaling pathways, SIKs play diverse roles in many physiological and pathological… read more here.

Keywords: salt inducible; disease; inducible kinases; phosphorylation ... See more keywords

An Epilepsy-Associated Mutation of Salt-Inducible Kinase 1 Increases the Susceptibility to Epileptic Seizures and Interferes with Adrenocorticotropic Hormone Therapy for Infantile Spasms in Mice

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23147927

Abstract: Six mutations in the salt-inducible kinase 1 (SIK1) have been identified in developmental and epileptic encephalopathy (DEE-30) patients, and two of the mutations are nonsense mutations that truncate the C-terminal region of SIK1. In a… read more here.

Keywords: salt inducible; nmda induced; epileptic seizures; sik1 ... See more keywords

Isolation and Characterization of a Salt Inducible Promoter from Chlorella vulgaris PKVL7422.

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recommendations! Published in 2023 at "Journal of microbiology and biotechnology"

DOI: 10.4014/jmb.2304.04005

Abstract: Chlorella is a eukaryotic organism that can be used as an industrial host to produce recombinant proteins. In this study, a salt-inducible promoter (SIP) was isolated from the freshwater species Chlorella vulgaris PKVL7422 from the… read more here.

Keywords: promoter; salt inducible; vulgaris; inducible promoter ... See more keywords