Fluorescence-Based High-Throughput Salt Screening.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.02.018
Abstract: The present study reports a high-throughput screening method for the salt formation of amine-containing active pharmaceutical ingredients (APIs) based on fluorescence measurements. A free form amine API was alkynylated by a solid-vapor reaction using propargyl… read more here.
Keywords: salt formation; salt screening; salt; amine ... See more keywords
Microbatch under-oil salt screening of organic cations: single-crystal growth of active pharmaceutical ingredients
Sign Up to like & getrecommendations! Published in 2019 at "IUCrJ"
DOI: 10.1107/s2052252518017876
Abstract: The under-oil crystallization method was successfully adopted for the crystallization of organic salts. Compared with the previously reported vapour-diffusion-based nano-crystallization technique, the under-oil method generated single crystals of more different salts for all studied compounds. read more here.
Keywords: screening organic; microbatch oil; oil; salt screening ... See more keywords