Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity
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DOI: 10.1038/s41440-018-0122-5
Abstract: High-salt intake is one of the major dietary determinants of increased blood pressure and cardiovascular disease. Thus, there is scientific and medical interest in understanding the mechanistic abnormalities mediating the pressor effects of salt (salt… read more here.
Keywords: salt induced; theory; salt; hypertension ... See more keywords
Evaluation of the pathophysiological mechanisms of salt-sensitive hypertension
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DOI: 10.1038/s41440-019-0332-5
Abstract: The currently available data have indicated that dietary salt is directly correlated with blood pressure (BP) and the occurrence of hypertension. However, the salt sensitivity of BP is different in each individual. Genetic factors and… read more here.
Keywords: salt; sensitive hypertension; salt sensitive; hypertension ... See more keywords
Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis
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DOI: 10.1038/s41598-019-48300-3
Abstract: Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of the mammalian kidney. It is the most abundant protein in normal urine. Defective uromodulin processing is associated with various kidney… read more here.
Keywords: salt; hepsin; uromodulin; thick ascending ... See more keywords
P4444Hypertension, autoimmune inflammation and salt sensitivity in women with rheumatoid arthritis
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DOI: 10.1093/eurheartj/ehz745.0845
Abstract: Hypertension (HTN) takes the first place among cardiovascular diseases in patients with rheumatoid arthritis (RA). Currently, the main risk factors for hypertension are known, but eating habits are often not considered in patients with RA.… read more here.
Keywords: sensitivity; autoimmune inflammation; hypertension; salt sensitivity ... See more keywords
SALT SENSITIVITY IS MODULATED BY LANOSTEROL SYNTHASE RS2254524 POLYMORPHISM
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DOI: 10.1097/01.hjh.0000837776.43946.db
Abstract: Objective: The blood pressure (BP) response to different salt intake is associated with hypertension (HT). Elevated levels of the steroid hormone Endogenous Ouabain (EO) have been also associated with HT and salt sensitivity. We characterized… read more here.
Keywords: low salt; lanosterol synthase; salt sensitivity; salt ... See more keywords
SALT-SENSITIVITY IN HEALTHY NORMOTENSIVE MEN IS ASSOCIATED WITH IMPAIRED BAROREFLEX SENSITIVITY
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DOI: 10.1097/01.hjh.0000838200.20009.90
Abstract: Objective: Blood pressure (BP) responses to Na+ intake show great variability, discriminating sodium sensitive (SS) from salt resistant (SR) individuals. The pathophysiology behind salt-sensitivity is still not fully elucidated. A pivotal role for the sympathetic… read more here.
Keywords: baroreflex sensitivity; sensitivity; normotensive men; xbrs ... See more keywords
The American Heart Association Scientific Statement on salt sensitivity of blood pressure: Prompting consideration of alternative conceptual frameworks for the pathogenesis of salt sensitivity?
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DOI: 10.1097/hjh.0000000000001458
Abstract: &NA; Recently, the American Heart Association (AHA) published a scientific statement on salt sensitivity of blood pressure which emphasized a decades old conceptual framework for the pathogenesis of this common disorder. Here we examine the… read more here.
Keywords: blood pressure; pathogenesis; sensitivity; statement ... See more keywords
Association of plasma cyclooxygenase-2 levels and genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults.
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DOI: 10.1097/hjh.0000000000002473
Abstract: OBJECTIVE Cyclooxygenase (COX)-2, an inducible isoform of the major rate-limiting enzymes that regulate the production of prostaglandins is associated with injury, inflammation and proliferation. We sought to examine whether plasma COX-2 levels and its genetic… read more here.
Keywords: cox; salt; hypertension; salt sensitivity ... See more keywords
Effects of environmental and genetic risk factors for salt sensitivity on blood pressure in northern China: the systemic epidemiology of salt sensitivity (EpiSS) cohort study
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DOI: 10.1136/bmjopen-2018-023042
Abstract: Purpose The systemic epidemiology of salt sensitivity (EpiSS) study aims to combine molecular biology, epidemiology and bioinformatics methods to discover the potential causes of salt sensitivity of blood pressure (SSBP) using single-nucleotide polymorphisms in the… read more here.
Keywords: study; epidemiology; blood pressure; salt sensitivity ... See more keywords
Challenges and Approach to Identifying Individuals with Salt Sensitivity of Blood Pressure
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DOI: 10.1159/000529057
Abstract: Background: Salt sensitivity of blood pressure (SSBP) is a trait observed in both humans and animals, characterized by an increase in blood pressure (BP) following salt loading or a drop in BP following salt depletion.… read more here.
Keywords: salt sensitivity; blood pressure; sensitivity blood; sensitivity ... See more keywords
Quantifying salt sensitivity
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DOI: 10.1515/hsz-2021-0206
Abstract: Abstract Inner surfaces of blood vessels and outer surfaces of erythrocytes are coated with a negatively charged protective film of proteoglycans, which serves as an effective buffer system for the positively charged sodium ions. If… read more here.
Keywords: sensitivity; chemistry; quantifying salt; salt sensitivity ... See more keywords